Literature summary for 3.5.1.3 extracted from

Hariharan, V.A.; Denton, T.T.; Paraszcszak, S.; McEvoy, K.; Jeitner, T.M.; Krasnikov, B.F.; Cooper, A.J.
The enzymology of 2-hydroxyglutarate, 2-hydroxyglutaramate and 2-hydroxysuccinamate and their relationship to oncometabolites (2017), Biology, 6, E24 .

Search for more literature for 3.5.1.3

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NQR4	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.51	-	substrate: L-2-hydroxysuccinamate, pH 7.4, 37°C	Homo sapiens
1.4	-	substrate: L-2-hydroxyglutaramate, pH 7.4, 37°C	Homo sapiens
3	-	substrate: 2-oxoglutaramate, pH 7.4, 37°C	Homo sapiens
3.4	-	substrate: succinamate, pH 7.4, 37°C	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-oxoglutaramate + H2O	-	Homo sapiens	2-oxoglutarate + NH3	-	?
2-oxosuccinamate + H2O	-	Homo sapiens	oxaloacetate + NH3	-	?
L-2-hydroxyglutaramate + H2O	-	Homo sapiens	L-2-hydroxyglutarate + NH3	-	?
L-2-hydroxysuccinamate + H2O	-	Homo sapiens	L-malate + NH3	-	?

Synonyms

Synonyms	Comment	Organism
NIT2	-	Homo sapiens
nitrilase-like protein 2	-	Homo sapiens
omega-amidase	-	Homo sapiens
omega-amidodicarboxylate amidohydrolase	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	the enzyme may be regarded as a repair enzyme for salvaging L-2-hydroxysuccinamate (as L-malate), and, working in conjunction with L-2-hydroxyglutarate dehydrogenase, for salvaging L-2-hydroxyglutaramate (as 2-oxoglutarate)	Homo sapiens

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Release 2023.1 (January 2023)