Inhibition of nicotinamide deaminase from Micrococcus lysodeikticus by analogues of nicotinamide
Johnson, W.J.; Gadd, R.E.A.; Int. J. Biochem. 5, 633-641 (1974)
No PubMed abstract available
Data extracted from this reference:
Inhibitors
Inhibitors
Commentary
Organism
Structure
3-(3-pyridyl)-1-propanol
moderate
Micrococcus luteus
3-acetylpyridine
moderate
Micrococcus luteus
3-aminomethylpyridine
potent
Micrococcus luteus
3-chloropyridine
moderate
Micrococcus luteus
3-Cyanopyridine
potent
Micrococcus luteus
3-Pyridineacetonitrile
moderate
Micrococcus luteus
3-pyridinealdoxime
potent
Micrococcus luteus
3-Pyridinecarboxaldehyde
potent
Micrococcus luteus
3-Pyridylcarbinol
potent
Micrococcus luteus
4-aminonicotinamide
potent
Micrococcus luteus
5-Methylnicotinamide
moderate
Micrococcus luteus
isoniazid
moderate
Micrococcus luteus
additional information
pyridine nitrogen and the carbonyl carbon of nicotinamide are involved in substrate-enzyme binding, and the enzyme exhibits steric hindrance in binding nicotinamide analogues with substituents at the 1-position, 5-position, and 6-positions of the pyridine ring
Micrococcus luteus
nicotinal hydroxamic acid
moderate
Micrococcus luteus
nicotinic acid hydrazide
potent
Micrococcus luteus
nipecotamide
moderate
Micrococcus luteus
o-bromobenzamide
moderate
Micrococcus luteus
Pyrazinamide
moderate
Micrococcus luteus
Thionicotinamide
moderate
Micrococcus luteus
Organism
Organism
UniProt
Commentary
Textmining
Micrococcus luteus
-
i.e. Micrococcus lysodeiktikus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
nicotinamide + H2O
-
246574
Micrococcus luteus
nicotinate + NH3
-
-
-
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
3-(3-pyridyl)-1-propanol
moderate
Micrococcus luteus
3-acetylpyridine
moderate
Micrococcus luteus
3-aminomethylpyridine
potent
Micrococcus luteus
3-chloropyridine
moderate
Micrococcus luteus
3-Cyanopyridine
potent
Micrococcus luteus
3-Pyridineacetonitrile
moderate
Micrococcus luteus
3-pyridinealdoxime
potent
Micrococcus luteus
3-Pyridinecarboxaldehyde
potent
Micrococcus luteus
3-Pyridylcarbinol
potent
Micrococcus luteus
4-aminonicotinamide
potent
Micrococcus luteus
5-Methylnicotinamide
moderate
Micrococcus luteus
isoniazid
moderate
Micrococcus luteus
additional information
pyridine nitrogen and the carbonyl carbon of nicotinamide are involved in substrate-enzyme binding, and the enzyme exhibits steric hindrance in binding nicotinamide analogues with substituents at the 1-position, 5-position, and 6-positions of the pyridine ring
Micrococcus luteus
nicotinal hydroxamic acid
moderate
Micrococcus luteus
nicotinic acid hydrazide
potent
Micrococcus luteus
nipecotamide
moderate
Micrococcus luteus
o-bromobenzamide
moderate
Micrococcus luteus
Pyrazinamide
moderate
Micrococcus luteus
Thionicotinamide
moderate
Micrococcus luteus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
nicotinamide + H2O
-
246574
Micrococcus luteus
nicotinate + NH3
-
-
-
?
Other publictions for EC 3.5.1.19
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Protein Variants
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
kcat/KM [mM/s]
kcat/KM [mM/s] (protein specific)
755521
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2
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1
1
1
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1
1
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1
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1
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1
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-
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2
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1
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1
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1
1
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-
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-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
2
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1
1
2
1
1
1
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-
-
2
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1
2
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5
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1
-
-
-
-
-
5
1
1
1
1
6
25
1
1
1
-
2
-
-
-
-
1
-
-
-
-
-
2
2
25
-
1
2
-
-
-
-
1
-
-
-
-
5
1
1
1
6
25
1
1
1
-
-
-
-
-
25
25
752546
Wang
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Appl. Environ. Microbiol.
82
5815-5823
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1
1
-
-
-
-
-
1
-
1
2
-
5
-
-
-
-
-
-
-
-
4
1
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
753679
Zapata-Perez
Combined whole-cell high-thro ...
uncultured bacterium, no activity in Homo sapiens, unidentified
Front. Microbiol.
7
1915
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2
2
-
-
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4
5
-
1
1
2
-
5
-
-
1
-
-
-
-
-
9
1
3
2
2
-
5
2
2
-
-
2
-
-
-
2
2
-
-
-
-
-
4
2
5
-
1
1
2
-
-
-
1
-
-
-
-
9
1
2
2
-
5
2
2
-
-
-
3
3
-
5
5
727053
Stekhanova
Nicotinamidase from the thermo ...
Acidilobus saccharovorans, Acidilobus saccharovorans DSM 16705
Biochemistry
79
54-61
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2
-
1
-
-
-
4
1
-
1
1
-
-
19
-
-
-
-
-
-
-
-
2
1
1
1
1
2
1
1
-
-
-
-
-
-
2
-
1
-
-
-
-
-
4
-
1
-
1
1
-
-
-
-
-
-
-
-
-
2
1
1
1
2
1
1
-
-
-
-
1
1
-
1
1
729184
Stekhanova
Nicotinamidase from the thermo ...
Acidilobus saccharovorans, Acidilobus saccharovorans DSM 16705
Biochemistry (Moscow)
79
54-61
2014
3
-
1
-
-
-
3
2
-
1
1
-
-
19
-
-
-
-
-
-
-
-
6
1
2
1
1
2
2
1
1
-
-
-
-
-
3
-
1
-
-
-
-
-
3
-
2
-
1
1
-
-
-
-
-
-
-
-
-
6
1
1
1
2
2
1
1
-
-
-
-
-
-
2
2
734741
Ion
A multi-scale computational st ...
Streptococcus pneumoniae
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19
15735-15753
2014
-
1
-
-
-
-
-
-
-
1
-
1
-
4
-
-
-
1
-
-
-
-
2
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
735324
Rueda
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Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
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-
-
1
-
-
-
-
-
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1
4
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19
-
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1
-
-
-
-
-
4
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
4
-
-
-
1
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
735084
Sanchez-Carron
Biochemical and mutational ana ...
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PLoS ONE
8
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2013
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1
-
9
-
2
27
-
2
2
4
-
10
-
-
1
-
-
-
28
-
12
1
1
1
1
1
26
1
1
1
-
2
-
-
-
-
1
-
-
9
-
-
2
2
27
-
2
2
4
-
-
-
1
-
-
28
-
12
1
1
1
1
26
1
1
1
-
-
2
2
-
26
26
718924
Smith
Structural and kinetic isotope ...
Saccharomyces cerevisiae
Biochemistry
51
243-256
2012
-
-
1
1
10
-
6
9
-
1
-
1
-
14
-
-
1
-
-
-
-
-
7
-
1
-
-
-
14
1
-
-
-
5
-
-
-
-
1
-
1
10
-
-
6
5
9
-
1
-
1
-
-
-
1
-
-
-
-
7
-
-
-
-
14
1
-
-
-
-
-
-
-
15
15
719619
Gazanion
Leishmania infantum nicotinami ...
Leishmania infantum
Int. J. Parasitol.
42
323-327
2012
-
-
-
-
1
-
-
-
-
-
-
1
-
14
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
735054
Zhang
Molecular dynamics simulations ...
Streptococcus pneumoniae, Acinetobacter baumannii
PLoS ONE
7
e39546
2012
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-
-
2
-
-
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-
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-
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4
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4
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-
-
-
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6
-
4
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2
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4
-
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-
-
-
-
-
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6
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
720499
Gazanion
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Leishmania infantum, Leishmania infantum MHOM/MA/67/ITMAP-263
Mol. Microbiol.
82
21-38
2011
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-
1
1
1
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-
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1
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2
4
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14
-
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1
-
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1
-
-
4
2
1
-
-
-
-
-
-
-
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1
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1
1
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1
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2
4
-
-
-
1
-
1
-
-
4
2
-
-
-
-
-
-
-
-
-
2
2
-
-
-
718859
French
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Borreliella burgdorferi, Saccharomyces cerevisiae, Caenorhabditis elegans, Streptococcus pneumoniae, Plasmodium falciparum
Biochemistry
49
10421-10439
2010
-
-
5
-
4
-
46
6
-
-
-
45
-
30
-
-
5
-
-
-
-
-
45
-
6
-
-
-
6
-
-
-
-
32
-
-
-
-
5
-
-
4
-
-
46
32
6
-
-
-
45
-
-
-
5
-
-
-
-
45
-
-
-
-
6
-
-
-
-
-
5
5
-
-
-
718883
French
High-resolution crystal struct ...
Streptococcus pneumoniae
Biochemistry
49
8803-8812
2010
-
-
1
1
1
-
2
-
-
5
1
1
-
12
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
2
-
-
-
5
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718885
Seiner
Kinetics and inhibition of nic ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Biochemistry
49
9613-9619
2010
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1
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1
-
4
4
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2
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4
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191
-
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1
-
-
-
-
-
4
-
2
-
-
-
4
1
-
-
-
2
-
-
-
-
1
-
-
1
-
-
4
2
4
-
2
-
4
-
-
-
1
-
-
-
-
4
-
-
-
-
4
1
-
-
-
-
1
1
-
4
4
710862
Fyfe
Specificity and mechanism of A ...
Acinetobacter baumannii
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-
-
-
-
-
-
-
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4
1
2
-
3
-
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-
1
-
-
-
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3
1
2
-
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-
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4
1
2
-
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-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
711827
Vrablik
Nicotinamidase modulation of N ...
Caenorhabditis elegans
Development
136
3637-3646
2009
-
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1
-
1
-
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1
1
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1
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10
-
-
-
-
-
-
-
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1
-
1
1
-
-
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1
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1
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1
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1
1
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1
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-
-
1
-
1
-
-
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1
-
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-
2
2
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679806
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Characterization of Mycobacter ...
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-
1
1
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2
1
2
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5
-
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1
-
-
-
2
-
2
1
2
1
-
1
-
1
-
1
-
-
-
-
-
1
1
-
-
9
-
-
-
-
-
-
2
1
2
-
-
-
1
-
-
2
-
2
1
1
-
1
-
1
-
1
-
-
-
-
-
-
-
697513
Chong
Enhanced tolerance against ear ...
Drosophila melanogaster
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5
159-170
2008
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1
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1
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1
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-
698121
McClure
Pnc1p-mediated nicotinamide cl ...
Saccharomyces cerevisiae
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180
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Reduced pyrazinamidase activit ...
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Identification, cloning, and e ...
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Increased nicotinamideadenine ...
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Wintzerith
Purification and characterizat ...
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Fuller
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Determination of nicotinamide ...
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Nicotinamide deamidase from Fl ...
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Pyridine nucleotide cycle of S ...
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Gillam
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Albizati
Active-site studies on rabbit ...
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246567
Sarma
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Studies on the enzymes involve ...
Aspergillus niger
Biochim. Biophys. Acta
81
311-322
1964
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