BRENDA - Reference to 3.5.1.19; Id = 246574

3-(3-pyridyl)-1-propanol

moderate

Micrococcus luteus

3-acetylpyridine

moderate

Micrococcus luteus

3-aminomethylpyridine

potent

Micrococcus luteus

3-chloropyridine

moderate

Micrococcus luteus

3-Cyanopyridine

potent

Micrococcus luteus

3-Pyridineacetonitrile

moderate

Micrococcus luteus

3-pyridinealdoxime

potent

Micrococcus luteus

3-Pyridinecarboxaldehyde

potent

Micrococcus luteus

3-Pyridylcarbinol

potent

Micrococcus luteus

4-aminonicotinamide

potent

Micrococcus luteus

5-Methylnicotinamide

moderate

Micrococcus luteus

isoniazid

moderate

Micrococcus luteus

additional information

pyridine nitrogen and the carbonyl carbon of nicotinamide are involved in substrate-enzyme binding, and the enzyme exhibits steric hindrance in binding nicotinamide analogues with substituents at the 1-position, 5-position, and 6-positions of the pyridine ring

Micrococcus luteus

nicotinal hydroxamic acid

moderate

Micrococcus luteus

nicotinic acid hydrazide

potent

Micrococcus luteus

nipecotamide

moderate

Micrococcus luteus

o-bromobenzamide

moderate

Micrococcus luteus

Pyrazinamide

moderate

Micrococcus luteus

Thionicotinamide

moderate

Micrococcus luteus

-

i.e. Micrococcus lysodeiktikus

-

nicotinamide + H2O

-

246574

Micrococcus luteus

nicotinate + NH3

-

?

3-(3-pyridyl)-1-propanol

moderate

Micrococcus luteus

3-acetylpyridine

moderate

Micrococcus luteus

3-aminomethylpyridine

potent

Micrococcus luteus

3-chloropyridine

moderate

Micrococcus luteus

3-Cyanopyridine

potent

Micrococcus luteus

3-Pyridineacetonitrile

moderate

Micrococcus luteus

3-pyridinealdoxime

potent

Micrococcus luteus

3-Pyridinecarboxaldehyde

potent

Micrococcus luteus

3-Pyridylcarbinol

potent

Micrococcus luteus

4-aminonicotinamide

potent

Micrococcus luteus

5-Methylnicotinamide

moderate

Micrococcus luteus

isoniazid

moderate

Micrococcus luteus

additional information

pyridine nitrogen and the carbonyl carbon of nicotinamide are involved in substrate-enzyme binding, and the enzyme exhibits steric hindrance in binding nicotinamide analogues with substituents at the 1-position, 5-position, and 6-positions of the pyridine ring

Micrococcus luteus

nicotinal hydroxamic acid

moderate

Micrococcus luteus

nicotinic acid hydrazide

potent

Micrococcus luteus

nipecotamide

moderate

Micrococcus luteus

o-bromobenzamide

moderate

Micrococcus luteus

Pyrazinamide

moderate

Micrococcus luteus

Thionicotinamide

moderate

Micrococcus luteus

nicotinamide + H2O

-

246574

Micrococcus luteus

nicotinate + NH3

-

?

727053

Stekhanova

Nicotinamidase from the thermo ...

Acidilobus saccharovorans, Acidilobus saccharovorans DSM 16705

Biochemistry

79

54-61

2014

2

-

1

-

4

1

-

1

-

7

-

2

1

2

1

-

2

-

1

-

4

-

1

-

1

-

2

1

2

1

-

1

-

1

729184

Stekhanova

Nicotinamidase from the thermo ...

Acidilobus saccharovorans, Acidilobus saccharovorans DSM 16705

Biochemistry (Moscow)

79

54-61

2014

3

-

1

-

3

2

-

1

-

7

-

6

1

2

1

-

3

-

1

-

3

-

2

-

1

-

6

1

2

1

-

2

734741

Ion

A multi-scale computational st ...

Streptococcus pneumoniae

Molecules

19

15735-15753

2014

-

1

-

1

-

1

-

2

-

1

-

2

-

1

-

1

-

1

-

2

-

3

-

735324

Rueda

Nicotinamidase/pyrazinamidase ...

Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv

Tuberculosis

94

644-648

2014

-

1

-

1

4

-

3

-

1

-

4

2

-

1

-

1

4

-

1

-

4

2

-

1

-

735084

Sanchez-Carron

Biochemical and mutational ana ...

Oceanobacillus iheyensis, Oceanobacillus iheyensis HTE831

PLoS ONE

8

e56727

2013

-

1

-

9

-

2

27

-

2

4

-

5

-

1

-

28

-

12

1

26

1

-

2

-

1

-

9

-

2

27

-

2

4

-

1

-

28

-

12

1

26

1

-

2

-

26

718924

Smith

Structural and kinetic isotope ...

Saccharomyces cerevisiae

Biochemistry

51

243-256

2012

-

1

10

-

6

8

-

1

-

1

-

6

-

1

-

7

-

12

1

-

5

-

1

-

1

10

-

6

5

8

-

1

-

1

-

1

-

7

-

12

1

-

15

719619

Gazanion

Leishmania infantum nicotinami ...

Leishmania infantum

Int. J. Parasitol.

42

323-327

2012

-

1

-

1

-

5

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

735054

Zhang

Molecular dynamics simulations ...

Acinetobacter baumannii, Streptococcus pneumoniae

PLoS ONE

7

e39546

2012

-

2

-

4

-

3

-

6

-

2

-

4

-

6

-

2

-

720499

Gazanion

The Leishmania nicotinamidase ...

Leishmania infantum, Leishmania infantum MHOM/MA/67/ITMAP-263

Mol. Microbiol.

82

21-38

2011

-

1

-

1

-

2

4

-

7

-

1

-

1

-

4

1

-

1

-

1

-

1

-

2

4

-

1

-

1

-

4

1

-

2

-

718859

French

Characterization of nicotinami ...

Borreliella burgdorferi, Caenorhabditis elegans, Plasmodium falciparum, Saccharomyces cerevisiae, Streptococcus pneumoniae

Biochemistry

49

10421-10439

2010

-

5

-

4

-

46

6

-

45

-

17

-

5

-

45

-

6

-

32

-

5

-

4

-

46

32

6

-

45

-

5

-

45

-

6

-

5

-

718883

French

High-resolution crystal struct ...

Streptococcus pneumoniae

Biochemistry

49

8803-8812

2010

-

1

-

2

-

5

1

-

5

-

1

-

1

-

1

-

1

-

2

-

5

1

-

1

-

1

-

718885

Seiner

Kinetics and inhibition of nic ...

Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv

Biochemistry

49

9613-9619

2010

-

1

-

1

-

4

-

2

-

4

-

162

-

1

-

4

-

4

1

-

2

-

1

-

1

-

4

2

4

-

2

-

4

-

1

-

4

-

4

1

-

1

-

4

710862

Fyfe

Specificity and mechanism of A ...

Acinetobacter baumannii

Angew. Chem. Int. Ed. Engl.

48

9176-9179

2009

-

4

1

2

-

2

-

1

-

3

1

-

4

1

2

-

3

1

-

2

-

711827

Vrablik

Nicotinamidase modulation of N ...

Caenorhabditis elegans

Development

136

3637-3646

2009

-

1

-

1

-

1

-

1

-

4

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

679806

Zhang

Characterization of Mycobacter ...

Mycobacterium tuberculosis

FEBS J.

275

753-762

2008

-

1

-

9

-

2

1

2

-

3

-

1

-

2

-

2

1

-

1

-

1

-

1

-

1

-

9

-

2

1

2

-

1

-

2

-

2

1

-

1

-

1

-

1

-

697513

Chong

Enhanced tolerance against ear ...

Drosophila melanogaster

Curr. Neurovasc. Res.

5

159-170

2008

-

1

-

2

-

1

-

698121

McClure

Pnc1p-mediated nicotinamide cl ...

Saccharomyces cerevisiae

Genetics

180

797-810

2008

-

2

-

698815

Balan

Life span extension and neuron ...

Drosophila melanogaster

J. Biol. Chem.

283

27810-27819

2008

-

1

-

1

-

6

-

1

-

1

-

2

1

-

1

-

1

-

1

-

1

-

2

1

-

700669

Yin

Changes in pyridine metabolism ...

Lotus japonicus

Phytochemistry

69

2891-2898

2008

-

2

-

1

-

1

-

677824

Hu

Crystal structure of the yeast ...

Saccharomyces cerevisiae

Arch. Biochem. Biophys.

461

66-75

2007

-

1

-

1

-

1

-

2

-

3

-

1

-

2

-

2

-

1

-

1

-

1

-

1

-

2

-

1

-

2

-

2

-

681746

van der Horst

The Caenorhabditis elegans nic ...

Caenorhabditis elegans

Mech. Ageing Dev.

128

346-349

2007

-

1

-

4

-

1

-

1

-

1

-

682376

Wang

Nicotinamidase participates in ...

Arabidopsis thaliana

Plant J.

49

1020-1029

2007

-

1

-

1

-

6

-

2

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

682380

Hunt

Nicotinamidase activity is imp ...

Arabidopsis thaliana

Plant J.

51

341-351

2007

2

-

1

-

3

-

1

-

3

-

1

-

1

-

2

-

1

-

3

-

1

-

1

-

1

-

659608

Zheng

Changes in trigonelline (N-met ...

Vigna radiata var. radiata

J. Exp. Bot.

56

1615-1623

2005

-

2

-

1

-

3

-

3

-

1

-

1

-

2

-

3

-

3

-

1

-

1

-

668655

Kim

Brucella abortus nicotinamidas ...

Brucella abortus, Brucella abortus 544 / ATCC 23448

FEMS Microbiol. Lett.

234

289-295

2004

-

1

-

2

-

2

-

8

-

1

-

4

-

1

-

2

-

2

-

1

-

4

-

670237

Gallo

Nicotinamide clearance by Pnc1 ...

Saccharomyces cerevisiae

Mol. Cell. Biol.

24

1301-1312

2004

1

-

1

-

2

-

1

-

2

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

2

-

246584

Guo

Mycobacterium smegmatis has tw ...

Mycolicibacterium smegmatis

J. Bacteriol.

182

3881-3884

2000

-

1

-

1

-

5

-

2

1

-

1

-

1

-

2

1

-

246583

Sun

Reduced pyrazinamidase activit ...

Mycobacterium kansasii

Antimicrob. Agents Chemother.

43

537-542

1999

-

1

-

8

-

2

-

1

-

2

-

246585

Boshoff

Purification, gene cloning, ta ...

Mycobacterium tuberculosis, Mycolicibacterium smegmatis

J. Bacteriol.

180

5809-5814

1998

-

1

-

2

-

5

-

1

-

4

-

1

-

2

-

1

-

4

-

246587

Raynaud

-

Extracellular enzyme activitie ...

Mycobacterium kansasii, Mycobacterium tuberculosis, Mycobacterium tuberculosis variant bovis, Mycolicibacterium fortuitum, Mycolicibacterium phlei

Microbiology

144

577-587

1998

-

6

-

5

-

5

-

6

-

5

-

246582

Frothingham

Identification, cloning, and e ...

Escherichia coli

Antimicrob. Agents Chemother.

40

1426-1431

1996

-

1

-

5

-

2

-

1

-

2

-

246586

Zrez

Increased nicotinamideadenine ...

Plasmodium falciparum

Blood

75

1705-1710

1990

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

2

-

246588

Kgayama

-

Purification and properties of ...

Pseudomonas sp., Pseudomonas sp. GDI 211

Agric. Biol. Chem.

54

2565-2571

1990

-

1

2

-

3

2

-

2

-

1

-

1

-

6

1

2

-

1

-

1

-

2

-

2

-

3

2

-

1

-

1

-

6

1

2

-

1

-

246581

Yan

Purification and characterizat ...

Saccharomyces cerevisiae

J. Biol. Chem.

262

9082-9087

1987

-

2

1

-

2

-

2

-

1

-

2

-

1

-

2

-

1

-

2

-

1

-

2

-

1

-

1627

Shibata

-

Tissue distribution of the enz ...

Rattus norvegicus

Agric. Biol. Chem.

50

3037-3041

1986

-

1

-

3

-

1

-

3

-

1

-

209135

Foster

NAD metabolism in Vibrio chole ...

Vibrio cholerae

J. Bacteriol.

149

368-371

1982

-

1

-

1

-

2

-

1

-

2

-

246576

Wintzerith

Purification and characterizat ...

Mus musculus

Biochim. Biophys. Acta

613

191-202

1980

1

-

1

13

2

-

3

1

-

1

-

1

-

1

-

1

2

1

-

2

-

3

-

1

-

1

-

13

-

2

-

3

1

-

1

-

1

-

1

2

1

-

2

-

3

-

246577

Fuller

-

Determination of nicotinamide ...

Saccharomyces cerevisiae

Methods Enzymol.

66

3-4

1980

-

1

-

1

-

1

-

1

-

1

-

246578

Tanigawa

Nicotinamide deamidase from Fl ...

Flavobacterium peregrinum

Methods Enzymol.

66

132-136

1980

-

1

11

1

-

1

-

1

-

1

-

1

-

2

-

1

-

11

-

1

-

1

-

1

-

1

-

2

-

246575

Foster

Pyridine nucleotide cycle of S ...

Salmonella enterica subsp. enterica serovar Typhimurium

J. Bacteriol.

138

957-961

1979

-

1

-

1

-

1

-

2

-

1

-

1

-

2

-

246573

Gadd

-

Kinetic studies of nicotinamid ...

Micrococcus luteus

Int. J. Biochem.

5

397-407

1974

-

3

2

-

1

-

2

-

3

-

1

-

3

-

2

-

2

-

3

-

1

-

246574

Johnson

-

Inhibition of nicotinamide dea ...

Micrococcus luteus

Int. J. Biochem.

5

633-641

1974

-

19

-

1

-

1

-

19

-

1

-

246572

Gillam

Nicotinamide deamidase from ra ...

Oryctolagus cuniculus

Arch. Biochem. Biophys.

157

268-284

1973

-

5

-

2

-

1

-

1

-

2

1

-

5

-

2

-

1

-

1

-

2

1

-

246570

Albizati

Active-site studies on rabbit ...

Oryctolagus cuniculus

Biochemistry

11

1508-1516

1972

-

7

-

1

-

1

-

1

-

2

1

-

2

1

-

7

-

1

-

1

-

2

1

-

2

1

-

246571

Tanigawa

Purification and properties of ...

Flavobacterium peregrinum

J. Biol. Chem.

247

8036-8042

1972

1

-

1

6

1

-

1

-

1

-

1

-

2

1

-

1

-

1

-

1

-

6

-

1

-

1

-

1

-

2

1

-

1

-

246569

Pardee

Hyperproduction and purificati ...

Escherichia coli

J. Biol. Chem.

246

6792-6796

1971

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

246568

Petrack

Nicotinamide deaminase from ma ...

Oryctolagus cuniculus, Rattus norvegicus

J. Biol. Chem.

240

1725-1730

1965

-

1

3

-

2

-

2

-

2

-

2

-

1

-

1

3

-

2

-

2

-

2

-

1

-

246567

Sarma

-

Studies on the enzymes involve ...

Aspergillus niger

Biochim. Biophys. Acta

81

311-322

1964

-

4

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

4

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

Inhibition of nicotinamide deaminase from Micrococcus lysodeikticus by analogues of nicotinamide

Data extracted from this reference: