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Literature summary for 3.5.1.19 extracted from

  • Johnson, W.J.; Gadd, R.E.A.
    Inhibition of nicotinamide deaminase from Micrococcus lysodeikticus by analogues of nicotinamide (1974), Int. J. Biochem., 5, 633-641.
No PubMed abstract available
Search for more literature for 3.5.1.19

Inhibitors

Inhibitors Comment Organism Structure
3-(3-pyridyl)-1-propanol moderate Micrococcus luteus
3-acetylpyridine moderate Micrococcus luteus
3-aminomethylpyridine potent Micrococcus luteus
3-chloropyridine moderate Micrococcus luteus
3-Cyanopyridine potent Micrococcus luteus
3-Pyridineacetonitrile moderate Micrococcus luteus
3-pyridinealdoxime potent Micrococcus luteus
3-Pyridinecarboxaldehyde potent Micrococcus luteus
3-Pyridylcarbinol potent Micrococcus luteus
4-aminonicotinamide potent Micrococcus luteus
5-Methylnicotinamide moderate Micrococcus luteus
isoniazid moderate Micrococcus luteus
additional information pyridine nitrogen and the carbonyl carbon of nicotinamide are involved in substrate-enzyme binding, and the enzyme exhibits steric hindrance in binding nicotinamide analogues with substituents at the 1-position, 5-position, and 6-positions of the pyridine ring Micrococcus luteus
nicotinal hydroxamic acid moderate Micrococcus luteus
nicotinic acid hydrazide potent Micrococcus luteus
nipecotamide moderate Micrococcus luteus
o-bromobenzamide moderate Micrococcus luteus
Pyrazinamide moderate Micrococcus luteus
Thionicotinamide moderate Micrococcus luteus

Organism

Organism UniProt Comment Textmining
Micrococcus luteus
-
 i.e. Micrococcus lysodeiktikus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide + H2O
-
 Micrococcus luteus nicotinate + NH3
-
 ?