Protein Variants | Comment | Organism |
---|---|---|
G17S | hypersensitive strain with point mutation in LpxC | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4R)-N-hydroxy-2-tricyclo[3.3.1.1-3,7]dec-1-yl-4,5-dihydro-1,3-oxazole-4-carboxamide | 1 microg/ml, high inhibitory activity | Escherichia coli | |
(R)-2-(2-bromophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, nearly complete loss of activity | Escherichia coli | |
(R)-2-(3,4-dichlorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, exellent biological activity | Escherichia coli | |
(R)-2-(3,4-difluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, exellent biological activity | Escherichia coli | |
(R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml | Escherichia coli | |
(R)-2-(3,5-dichlorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, moderate activity | Escherichia coli | |
(R)-2-(3,5-difluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, good activity | Escherichia coli | |
(R)-2-(3,5-difluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, moderate activity | Escherichia coli | |
(R)-2-(3,5-dimethoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, 67% inhibition | Escherichia coli | |
(R)-2-(3-(dichloromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml | Escherichia coli | |
(R)-2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, exellent biological activity | Escherichia coli | |
(R)-2-(3-chloro-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, exellent biological activity | Escherichia coli | |
(R)-2-(3-cyanophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml | Escherichia coli | |
(R)-2-(3-fluoro-4-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, slight lower inhibitory activity than (R)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | Escherichia coli | |
(R)-2-(3-fluoro-5-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, good activity | Escherichia coli | |
(R)-2-(4-(hexyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, 86% inhibition | Escherichia coli | |
(R)-2-(4-(hydroxycarbamoyl)-4,5-dihydrooxazol-2-yl)benzyl benzoate | 1 microg/ml, nearly complete loss of activity | Escherichia coli | |
(R)-2-(4-chloro-3-nitrophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml | Escherichia coli | |
(R)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, most potent compound | Escherichia coli | |
(R)-2-(4-fluoro-3-nitrophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml | Escherichia coli | |
(R)-2-(4-tert-butylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, 58% inhibition | Escherichia coli | |
(R)-2-(biphenyl-4-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, 69% inhibition | Escherichia coli | |
(R)-2-decyl-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, high inhibitory activity | Escherichia coli | |
(R)-N-hydroxy-2-(2,3,5-trifluoro-4-methoxyphenyl)-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, good activity | Escherichia coli | |
(R)-N-hydroxy-2-(2-methylprop-1-enyl)-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, moderate activity | Escherichia coli | |
(R)-N-hydroxy-2-(3,4,5-triethoxyphenyl)-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, 72% inhibition | Escherichia coli | |
(R)-N-hydroxy-2-(3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, exellent inhibitory activity | Escherichia coli | |
(R)-N-hydroxy-2-(3-methoxyphenyl)-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, 44% inhibition | Escherichia coli | |
(R)-N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml | Escherichia coli | |
(R)-N-hydroxy-2-(4-methoxy-3,5-dimethylphenyl)-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, 71% inhibition | Escherichia coli | |
(R)-N-hydroxy-2-(4-methoxy-3-nitrophenyl)-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml | Escherichia coli | |
(R)-N-hydroxy-2-(4-methoxyphenyl)-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml | Escherichia coli | |
(R)-N-hydroxy-2-(4-methyl-3-nitrophenyl)-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml | Escherichia coli | |
(R)-N-hydroxy-2-(4-nitrophenyl)-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml | Escherichia coli | |
(R,E)-2-(2-chlorostyryl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, moderate activity | Escherichia coli | |
(R,E)-N-hydroxy-2-(3-(trifluoromethyl)styryl)-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, moderate activity | Escherichia coli | |
(R,E)-N-hydroxy-2-(4-nitrostyryl)-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, moderate activity | Escherichia coli | |
(R,E)-N-hydroxy-2-styryl-4,5-dihydrooxazole-4-carboxamide | 1 microg/ml, moderate activity | Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc amidase | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Escherichia coli | catalyses the second step of lipid A biosynthesis in Gram-negative bacteria | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
wild-type and LpxC inhibitor-sensitive strain | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | catalyses the second step of lipid A biosynthesis in Gram-negative bacteria | Escherichia coli | ? | - |
? | |
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O | - |
Escherichia coli | UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
deacetylase | - |
Escherichia coli |
LpxC | - |
Escherichia coli |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000097 | - |
- |
Escherichia coli | (R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
0.00033 | - |
- |
Escherichia coli | (R)-2-(3,5-difluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
0.00075 | - |
- |
Escherichia coli | (R)-2-(4-(hexyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
0.0016 | - |
- |
Escherichia coli | (R)-N-hydroxy-2-(2,3,5-trifluoro-4-methoxyphenyl)-4,5-dihydrooxazole-4-carboxamide | |
0.0068 | - |
- |
Escherichia coli | (R)-2-(3,5-difluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide |