Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.1.103 extracted from

  • Rawat, M.; Kovacevic, S.; Billman-Jacobe, H.; Av-Gay, Y.
    Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis (2003), Microbiology, 149, 1341-1349.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mycolicibacterium smegmatis MshB activity as a control point regulating mycothiol production ?
-
?
additional information Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 MshB activity as a control point regulating mycothiol production ?
-
?

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis
-
-
-
Mycolicibacterium smegmatis A0R2I7
-
-
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 A0R2I7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MshB activity as a control point regulating mycothiol production Mycolicibacterium smegmatis ?
-
?
additional information MshB activity as a control point regulating mycothiol production Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 ?
-
?

Synonyms

Synonyms Comment Organism
MshB
-
Mycolicibacterium smegmatis

General Information

General Information Comment Organism
malfunction disruption of mshB in Mycobacterium smegmatis results in decreased production of mycothiol (5Ā–10% of the parent strain mc2155) but does not abolish mycothiol synthesis completely. Complementation of the MshB2 mutants with the mshB gene results in increased mycothiol production towards the exponential and stationary phases of the bacterial growth cycle. The results suggest that another enzyme is capable of mycothiol biosynthesis by providing N-acetylglucosaminylinositol deacetylation activity in the absence of MshB Mycolicibacterium smegmatis