Literature summary for 3.4.24.B9 extracted from

Baggen, J.; Jan Thibaut, H.; Hurdiss, D.; Wahedi, M.; Van Vliet, A.; Van Kuppeveld, F.
Identification of the cell-surface protease adam9 as an entry factor for encephalomyocarditis virus (2019), mBio, 10, e1780 .

Search for more literature for 3.4.24.B9

Application

Application	Comment	Organism
medicine	cells lacking ADAM9 show a significant reduction in infection efficiency by encephalomyocarditis virus EMCV. Pharmacological inhibition of the metalloproteinase activity of ADAM9 does not affect virus infection. Reconstitution of inactive ADAM9 in knockout cells restores susceptibility to EMCV. ADAM9 facilitates attachment of EMCV to the cell surface	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell surface	-	Homo sapiens	9986	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13443	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HAP-1 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	cells lacking ADAM9 show a significant reduction in infection efficiency by encephalomyocarditis virus EMCV. Pharmacological inhibition of the metalloproteinase activity of ADAM9 does not affect virus infection. Reconstitution of inactive ADAM9 in knockout cells restores susceptibility to EMCV. ADAM9 facilitates attachment of EMCV to the cell surface	Homo sapiens

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Release 2023.1 (January 2023)