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Literature summary for 3.4.24.B9 extracted from
- A secreted form of human ADAM9 has an alpha-secretase activity for APP (2002), Biochem. Biophys. Res. Commun., 293, 800-805.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DNA sequence determination and analysis, expression of the short enzyme form, lacking the transmembrane and the cytoplasmic domains due to a deletion in the EGF-like domain, in COS cells, coexpression of amyloid precursor protein | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | metalloproteases | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| proteins + H2O | Homo sapiens | enzymes of the ADAM family play importants roles in cell-cell fusion, intracellular signaling, and other cellular functions | peptides | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q13443 | native short form of ADAM9 lacking the transmembrane and the cytoplasmic domains due to a deletion in the EGF-like domain | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | expression of full length and short enzyme form | Homo sapiens | - |
| heart | expression of full length and short enzyme form | Homo sapiens | - |
| liver | expression of full length and short enzyme form, with higher level of the short form than in other tissues | Homo sapiens | - |
| lung | expression of full length and short enzyme form | Homo sapiens | - |
| trachea | expression of full length and short enzyme form | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid precursor protein + H2O | enzyme shows alpha-secretase activity | Homo sapiens | ? | - |
? | |
| proteins + H2O | - |
Homo sapiens | peptides | - |
? | |
| proteins + H2O | enzymes of the ADAM family play importants roles in cell-cell fusion, intracellular signaling, and other cellular functions | Homo sapiens | peptides | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAM9 | - |
Homo sapiens |
| M12.209 | Merops-ID | Homo sapiens |
| MDC9 | - |
Homo sapiens |
| meltrin-gamma | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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