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Literature summary for 3.4.24.B8 extracted from
- Differential localization of ADAM1a and ADAM1b in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm (2003), Biochem. Biophys. Res. Commun., 304, 313-319.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | of germ cells, contains exclusively isozyme a | Mus musculus | 5783 | - |
| membrane | cell surface fof epididymal sperm, contains exclusively isozyme b | Mus musculus | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 48000 | - |
x * 48000, mature isozyme a, SDS-PAGE, x * 60000, mature isozyme b, SDS-PAGE, x * 100000, precursor of isozyme a, SDS-PAGE, x * 120000, precursor of isozyme b, SDS-PAGE | Mus musculus |
| 60000 | - |
x * 48000, mature isozyme a, SDS-PAGE, x * 60000, mature isozyme b, SDS-PAGE, x * 100000, precursor of isozyme a, SDS-PAGE, x * 120000, precursor of isozyme b, SDS-PAGE | Mus musculus |
| 100000 | - |
x * 48000, mature isozyme a, SDS-PAGE, x * 60000, mature isozyme b, SDS-PAGE, x * 100000, precursor of isozyme a, SDS-PAGE, x * 120000, precursor of isozyme b, SDS-PAGE | Mus musculus |
| 120000 | - |
x * 48000, mature isozyme a, SDS-PAGE, x * 60000, mature isozyme b, SDS-PAGE, x * 100000, precursor of isozyme a, SDS-PAGE, x * 120000, precursor of isozyme b, SDS-PAGE | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| proteins + H2O | Mus musculus | potential roles of isozyme a and b in spermatogenesis and fertilization | peptides | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
2 isozymes A and B | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | N-glycosylation | Mus musculus |
| proteolytic modification | isozyme a is partially processed to a 48 kDa mature protein in round and elongating spermatids, isozyme b precursor is totally processed to a 63 kDa intermediate during spermatogenesis and finally to a 60 kDa mature protein during sperm transit in the epididymis | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| germ cell | isozyme a | Mus musculus | - |
| additional information | isozymes precursors form in each case a heterodimer with ADAM2 | Mus musculus | - |
| sperm | epididymal, isozyme b | Mus musculus | - |
| testis | 2 isozymes | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| proteins + H2O | - |
Mus musculus | peptides | - |
? | |
| proteins + H2O | potential roles of isozyme a and b in spermatogenesis and fertilization | Mus musculus | peptides | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 48000, mature isozyme a, SDS-PAGE, x * 60000, mature isozyme b, SDS-PAGE, x * 100000, precursor of isozyme a, SDS-PAGE, x * 120000, precursor of isozyme b, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| a disintegrin and metalloprotease 1 | - |
Mus musculus |
| ADAM1 | - |
Mus musculus |
| fertilin alpha | heterodimeric protein consisting of ADAM1 and ADAM2 located on the surface of sperm | Mus musculus |
| M12.201 | Merops-ID | Mus musculus |
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