Protein Variants | Comment | Organism |
---|---|---|
additional information | MMP15 enzyme knockout in mammary gland epithelial cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular matrix | - |
Mus musculus | 31012 | - |
membrane | membrane-anchored | Mus musculus | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O54732 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Mus musculus | - |
adipocyte | of mammary gland | Mus musculus | - |
brown fat | - |
Mus musculus | - |
epithelial cell | - |
Mus musculus | - |
mammary gland | - |
Mus musculus | - |
mammary gland | MMP15 transcriptome profiling, overview | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
MMP15 | - |
Mus musculus |
MT2-MMP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | branching morphogenesis is thought to depend on the mobilization of the membrane-anchored matrix metalloproteinases MMP14 (MT1-MMP) and MMP15 (MT2-MMP), which drive epithelial cell invasion by remodeling the extracellular matrix and triggering associated signaling cascades. Different roles played by MMP14 or MMP15 in the mammary gland epithelial compartment and in development of mammary gland, overview. Whereas MMP14 promotes white fat-associated adipogenesis in the developing mammary gland, MMP15 serves as an endogenous suppressor of beige/brown fat production | Mus musculus |
physiological function | metalloproteinase MMP15 (MT2-MMP) drives epithelial cell invasion by remodeling the extracellular matrix and triggering associated signaling cascades. It plays a role in mammary gland development. Transcriptome profiling reveals a key role for MMP14 and MMP15 in regulating mammary gland adipocyte differentiation. MMP15 differentially controls the formation of thermogenic brown fat. Neonatal mammary gland branching proceeds in the absence of MMP15, early mammary epithelial branching is Mmp15 independent | Mus musculus |