Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13444 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | expression of ADAM15 natural isoforms in MDA-MB-231 cells leads to cell clustering to varying degree, without changes in epithelial mesenchymal transition markers vimentin, slug and E-cadherin. Expression leads to ADAM15 isoform specific, catalytic function dependent upregulation of claudin-1. The expression of ADAM15A, and to a lesser degree of C and E isoforms leads to an increase in claudin-1 expression in MDA-MB-231 cells, while ADAM15B has no effect. In MCF-7 cells, ADAM15E is the principal variant inducing claudin-1 expression. The PI3K/Akt/mTOR pathway is involved in regulating claudin-1 expression downstream of ADAM15. ADAM15 co-localizes with claudin-1 and ZO1 at cell-cell junctions | Homo sapiens |