Literature summary for 3.4.24.B28 extracted from

Dong, D.D.; Zhou, H.; Li, G.
ADAM15 targets MMP9 activity to promote lung cancer cell invasion (2015), Oncol. Rep., 34, 2451-2460 .

Search for more literature for 3.4.24.B28

Application

Application	Comment	Organism
medicine	high expression of ADAM15 is associated with decreased overall survival and disease-free survival in non-small cell lung cancer (NSCLC) patients. shRNA-mediated knockdown of ADAM15 attenuates cell migration and invasion. ADAM15 upregulates MMP9 expression in lung cancer cells via activation of the MEK-ERK pathway. ADAM15 proteolytically cleaves and activates pro-MMP9 in vitro and interacts with MMP9 in vivo. Overexpression of ADAM15 in A-549 cells promotes cell invasion, while knocking down MMP9 attenuates cell invasive ability	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13444	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Homo sapiens	-
lung cancer cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	shRNA-mediated knockdown of ADAM15 attenuates cell migration and invasion. ADAM15 upregulates MMP9 expression in lung cancer cells via activation of the MEK-ERK pathway. ADAM15 proteolytically cleaves and activates pro-MMP9 in vitro and interacts with MMP9 in vivo. Overexpression of ADAM15 in A-549 cells promotes cell invasion, while knocking down MMP9 attenuates cell invasive ability	Homo sapiens

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Release 2023.1 (January 2023)