Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13444 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
synovial fibroblast | - |
Homo sapiens | - |
synovial membrane | - |
Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is up-regulated in the rheumatoid arthritis synovial membrane | up |
General Information | Comment | Organism |
---|---|---|
malfunction | rheumatoid arthritis synovial fibroblasts display significantly higher caspase 3/7 activity upon camptothecin and FasL exposure when ADAM15 is down-regulated by specific small interfering RNAs. There is also a marked reduction of apoptosis upon knockdown of ADAM15 protein expression | Homo sapiens |
physiological function | the enzyme contributes to apoptosis resistance in rheumatoid arthritis synovial fibroblasts by activating the Src/focal adhesion kinase pathway upon FasL exposure | Homo sapiens |