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Literature summary for 3.4.24.B17 extracted from

  • Herman, C.; Prakash, S.; Lu, C.Z.; Matouschek, A.; Gross, C.A.
    Lack of a robust unfoldase activity confers a unique level of substrate specificity to the universal AAA protease FtsH (2003), Mol. Cell, 11, 659-669.
    View publication on PubMed
Search for more literature for 3.4.24.B17

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral, active site facing the cytoplasm Escherichia coli 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ metalloprotease Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein + H2O Escherichia coli housekeeping function, because the enzyme lacks a robust unfoldase activity, it is able to use the substrate protein folding state as a criterion for degradation peptides
-
 ?
protein SecY + H2O Escherichia coli uncomplexed subunit of the protein translocase ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Reaction

Reaction Comment Organism Reaction ID
proteolytic degradation of proteins mechanism, reaction only occurs with protein substrates of low intrinsic thermodynamic stability, sequential degradation from the tail Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
barnase tagged with SsrA tail + H2O tail specific degradation Escherichia coli ?
-
 ?
dihydrofolate reductase tagged with SsrA tail + H2O tail specific degradation Escherichia coli ?
-
 ?
additional information no activity with GFP-tagged proteins Escherichia coli ?
-
 ?
protein + H2O enzyme recognizes nonpolar tails, overview, degrades integral and cytoplasmic proteins Escherichia coli peptides
-
 ?
protein + H2O housekeeping function, because the enzyme lacks a robust unfoldase activity, it is able to use the substrate protein folding state as a criterion for degradation Escherichia coli peptides
-
 ?
protein P22 Arc repressor tagged with 108 motif tail + H2O tail specific degradation Escherichia coli ?
-
 ?
protein P22 Arc repressor tagged with SsrA tail + H2O tail specific degradation Escherichia coli ?
-
 ?
protein SecY + H2O uncomplexed subunit of the protein translocase Escherichia coli ?
-
 ?
protein sigma32 + H2O regulatory protein Escherichia coli ?
-
 ?

Synonyms

Synonyms Comment Organism
FtsH
-
 Escherichia coli
M41.001 Merops-ID Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP dependent on, enzyme is the only essential ATP-dependent protease in Escherichia coli Escherichia coli