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Literature summary for 3.4.24.B17 extracted from

  • Chiba, S.; Akiyama, Y.; Ito, K.
    Membrane protein degradation by FtsH can be initiated from either end (2002), J. Bacteriol., 184, 4775-4782.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B17

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral Escherichia coli 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein + H2O Escherichia coli
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Reaction

Reaction Comment Organism Reaction ID
proteolytic degradation of proteins mechanism Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chimeric protein PhoA-TM8-C30 + H2O recombinant substrate protein consists of one transmembrane segment of protein SecY, i.e. TM8, plus the following 30 residues of a cytoplasmic part, and the C-terminal end of alkaline phosphatase PhoA Escherichia coli ?
-
 ?
fusion protein SecY-(P5)-PhoA + H2O recombinant substrate protein consists of one protein SecY without its C-terminus, and the alkaline phosphatase PhoA Escherichia coli ?
-
 ?
protein + H2O
-
 Escherichia coli peptides
-
 ?
protein + H2O substrate specificity, soluble and integral membrane proteins, initiation of degradation by recognition and binding of more than 20 amino acids of the C-terminal cytosolic tail of the substrate, subsequently the substrate can be dislocated into the cytosol or degraded simultaneously bidirectionally Escherichia coli peptides
-
 ?
protein SecY + H2O
-
 Escherichia coli ?
-
 ?

Synonyms

Synonyms Comment Organism
FtsH
-
 Escherichia coli
M41.001 Merops-ID Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Escherichia coli