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Literature summary for 3.4.24.B12 extracted from

  • Troeberg, L.; Fushimi, K.; Scilabra, S.D.; Nakamura, H.; Dive, V.; Thogersen, I.B.; Enghild, J.J.; Nagase, H.
    The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3 (2009), Matrix Biol., 28, 463-469.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B12

Inhibitors

Inhibitors Comment Organism Structure
N-terminal domain of tissue inhibitor of metalloproteinases-3 all isoforms of ADAMTS-5 are effectively inhibited. Inhibited more strongly by N-terminal domain of tissue inhibitor of metalloproteinases-3 than by full-length tissue inhibitor of metalloproteinases-3 Homo sapiens
tissue inhibitor of metalloproteinases-3 all isoforms of ADAMTS-5 are effectively inhibited. Inhibited more strongly by N-terminal domain of tissue inhibitor of metalloproteinases-3 than by full-length tissue inhibitor of metalloproteinases-3 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinantly expressed in Escherichia coli
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
o-aminobenzoyl-Thr-Glu-Ser-Glu-Ser-Arg-Gly-Ala-Ile-Tyr-(N-3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-Lys-Lys-NH2 + H2O recombinant ADAMTS-5 cleaves this substrate more readily than ADAMTS-4 in vitro Homo sapiens o-aminobenzoyl-Thr-Glu-Ser-Glu + Ser-Arg-Gly-Ala-Ile-Tyr-(N-3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-Lys-Lys-NH2
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS-5
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00013
-
 N-terminal domain of tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS5-1 Homo sapiens
0.00029
-
 N-terminal domain of tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS5-3 Homo sapiens
0.00035
-
 N-terminal domain of tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS5-2 Homo sapiens
0.0004
-
 N-terminal domain of tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS5-4 Homo sapiens
0.00063
-
 tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS5-1 Homo sapiens
0.00072
-
 tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS5-2 Homo sapiens
0.001
-
 tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS5-3 Homo sapiens
0.00101
-
 N-terminal domain of tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS5-5 Homo sapiens
0.00113
-
 tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS5-4 Homo sapiens
0.00117
-
 tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS5-5 Homo sapiens