Inhibitors | Comment | Organism | Structure |
---|---|---|---|
doxycycline | dose-dependently inhibits the activity of rhADAMTS4 in vitro | Homo sapiens | |
minocycline | dose-dependently inhibits the activity of rhADAMTS4 in vitro | Homo sapiens | |
tetracycline | dose-dependently inhibits the activity of rhADAMTS4 in vitro | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aggrecan-interglobular domain + H2O | an aggrecan peptide with the N-terminal sequence ARGSVIL is released and quantified | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS5 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0707 | - |
pH and temperature not specified in the publication | Homo sapiens | doxycycline | |
0.111 | - |
pH and temperature not specified in the publication | Homo sapiens | minocycline | |
0.899 | - |
pH and temperature not specified in the publication | Homo sapiens | tetracycline |