Literature summary for 3.4.24.B12 extracted from

Sharghi-Namini, S.; Fan, H.; Sulochana, K.N.; Potturi, P.; Xiang, W.; Chong, Y.S.; Wang, Z.; Yang, H.; Ge, R.
The first but not the second thrombospondin type 1 repeat of ADAMTS5 functions as an angiogenesis inhibitor (2008), Biochem. Biophys. Res. Commun., 371, 215-219.

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Application

Application	Comment	Organism
medicine	the first thrombospondin type 1 repeat domain of ADAMTS5, unlike the second, has anti-angiogenic activities, ADAMTS5 is therefore an anti-angiogenic peptide and may serve as a prototype for future development into anti-cancer drugs	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
the first thrombospondin type 1 repeat is expressed in Escherichia coli strain BL21DE3	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA affinity chromatography	Homo sapiens

Synonyms

Synonyms	Comment	Organism
a disintegrin and metalloprotease with thrombospondin motifs 5	-	Homo sapiens
ADAMTS5	-	Homo sapiens
aggrecanase-2	-	Homo sapiens

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Release 2023.1 (January 2023)