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Literature summary for 3.4.24.B10 extracted from

  • Beristain, A.; Zhu, H.; Leung, P.
    Regulated expression of ADAMTS-12 in human trophoblastic cells: A role for ADAMTS-12 in epithelial cell invasion? (2011), PLoS ONE, 6, e18473.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B10

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin-like growth factor binding protein-3 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JEG-3 cell
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
trophoblast extravillous cytotrophoblast Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin-like growth factor binding protein-3 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS-12
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens a significant decrease in ADAMTS-12 mRNA levels is detected in extravillous cytotrophoblasts cultured in the presence of transforming growth factor-beta1 (1 ng/ml) for 24 - 48 h down
Homo sapiens ADAMTS-12 mRNA levels in extravillous cytotrophoblasts are significantly higher than those detected in JEG-3 cell. Interleukin-1beta causes a continuous and significant increase in ADAMTS-12 mRNA levels in extravillous cytotrophoblasts over time in culture up

General Information

General Information Comment Organism
physiological function ADAMTS-12, independent of its proteolytic activity, plays a specific, non-redundant role in trophoblast invasion. ADAMTS-12 regulates cell-extracellular matrix adhesion and invasion through a mechanism involving the alphavbeta3 integrin heterodimer Homo sapiens