Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Cavia porcellus | - |
- |
extracellular | - |
Mus musculus | - |
- |
extracellular | - |
Homo sapiens | - |
- |
extracellular | - |
Rattus norvegicus | - |
- |
extracellular | - |
Sus scrofa | - |
- |
extracellular | - |
Oryctolagus cuniculus | - |
- |
extracellular | - |
Canis lupus familiaris | - |
- |
extracellular | - |
Macaca fascicularis | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ba2+ | activates | Cavia porcellus | |
Ba2+ | activates | Mus musculus | |
Ba2+ | activates | Homo sapiens | |
Ba2+ | activates | Rattus norvegicus | |
Ba2+ | activates | Sus scrofa | |
Ba2+ | activates | Oryctolagus cuniculus | |
Ba2+ | activates | Canis lupus familiaris | |
Ba2+ | activates | Macaca fascicularis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | Cavia porcellus | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | Mus musculus | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | Homo sapiens | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | Rattus norvegicus | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | Sus scrofa | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | Oryctolagus cuniculus | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | Canis lupus familiaris | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | Macaca fascicularis | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
beagle dogs | - |
Cavia porcellus | - |
Dunkin Hartley guinea pigs | - |
Homo sapiens | - |
- |
- |
Macaca fascicularis | - |
cynomolgus monkey | - |
Mus musculus | - |
wild-type strain C57BL/6J mice, the isogenic von Willebrand factor-deficient strain 129x1/SvJ, and the ADAMTS13-deficient gene knock-out strain CAST/EiJ | - |
Oryctolagus cuniculus | - |
New Zealand white rabbits | - |
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Sus scrofa | - |
Yorkshire strain | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Cavia porcellus | - |
plasma | - |
Mus musculus | - |
plasma | - |
Homo sapiens | - |
plasma | - |
Rattus norvegicus | - |
plasma | - |
Sus scrofa | - |
plasma | - |
Oryctolagus cuniculus | - |
plasma | - |
Canis lupus familiaris | - |
plasma | - |
Macaca fascicularis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models | Cavia porcellus | ? | - |
? | |
additional information | differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models | Homo sapiens | ? | - |
? | |
additional information | differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models | Rattus norvegicus | ? | - |
? | |
additional information | differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models | Sus scrofa | ? | - |
? | |
additional information | differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models | Oryctolagus cuniculus | ? | - |
? | |
additional information | differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models | Canis lupus familiaris | ? | - |
? | |
additional information | differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models | Macaca fascicularis | ? | - |
? | |
additional information | no activity in von Willebrand factor-deficient or ADAMTS13-deficient mice with the recombinant substrate of human origin. Differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models | Mus musculus | ? | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | Cavia porcellus | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | Mus musculus | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | Homo sapiens | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | Rattus norvegicus | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | Sus scrofa | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | Oryctolagus cuniculus | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | Canis lupus familiaris | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain | Macaca fascicularis | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. Activity with the recombinant human substrate in vitro, comparison to other mammal enzymes, overview | Macaca fascicularis | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. Comparison of the activity with human recombinan substrate in vitro with enzymes from other mammal enzymes, overview | Homo sapiens | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. The guinea pig ADAMTS13 shows no activity with the recombinant human substrate in vitro, comparison to other mammal enzymes, overview | Cavia porcellus | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. The rabbit ADAMTS13 shows activity similar to the human ADAMTS13 with the recombinant human substrate in vitro, comparison to other mammal enzymes, overview | Oryctolagus cuniculus | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. The rat ADAMTS13 shows no activity with the recombinant human substrate in vitro, comparison to other mammal enzymes, overview | Rattus norvegicus | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. The wild-type mouse ADAMTS13 shows no activity with the recombinant human substrate in vitro, comparison to other mammal enzymes, overview | Mus musculus | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. Very low activity with recombinant human substrate in vitro, comparison to other mammal enzymes, overview | Sus scrofa | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. Very low activity with recombinant human substrate in vitro, comparison to other mammal enzymes, overview | Canis lupus familiaris | von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS13 | - |
Cavia porcellus |
ADAMTS13 | - |
Mus musculus |
ADAMTS13 | - |
Homo sapiens |
ADAMTS13 | - |
Rattus norvegicus |
ADAMTS13 | - |
Sus scrofa |
ADAMTS13 | - |
Oryctolagus cuniculus |
ADAMTS13 | - |
Canis lupus familiaris |
ADAMTS13 | - |
Macaca fascicularis |
plasma metalloprotease ADAMTS13 | - |
Cavia porcellus |
plasma metalloprotease ADAMTS13 | - |
Mus musculus |
plasma metalloprotease ADAMTS13 | - |
Homo sapiens |
plasma metalloprotease ADAMTS13 | - |
Rattus norvegicus |
plasma metalloprotease ADAMTS13 | - |
Sus scrofa |
plasma metalloprotease ADAMTS13 | - |
Oryctolagus cuniculus |
plasma metalloprotease ADAMTS13 | - |
Canis lupus familiaris |
plasma metalloprotease ADAMTS13 | - |
Macaca fascicularis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Cavia porcellus |
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Rattus norvegicus |
37 | - |
assay at | Sus scrofa |
37 | - |
assay at | Oryctolagus cuniculus |
37 | - |
assay at | Canis lupus familiaris |
37 | - |
assay at | Macaca fascicularis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Cavia porcellus |
8 | - |
assay at | Mus musculus |
8 | - |
assay at | Homo sapiens |
8 | - |
assay at | Rattus norvegicus |
8 | - |
assay at | Sus scrofa |
8 | - |
assay at | Oryctolagus cuniculus |
8 | - |
assay at | Canis lupus familiaris |
8 | - |
assay at | Macaca fascicularis |