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Literature summary for 3.4.24.87 extracted from
- Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13 (2010), Blood, 115, 706-712.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| HOCl | HOCl can oxidize methionine to methionine sulfoxide and tyrosine to chlorotyrosine, oxidation of VWF A2 peptide, at Met1606 and Tyr1605, markedly impairs ADAMTS13 cleavage. Oxidative modification by myeloperoxidase/H2O2 is similar to that produced by HOCl | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ba2+ | activates | Homo sapiens | |
| Zn2+ | required | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| von Willebrand factor + H2O | Homo sapiens | - |
von Willebrand factor fragments | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
ADAMTS13 Val900 polymorphic form | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| von Willebrand factor + H2O | - |
Homo sapiens | von Willebrand factor fragments | - |
? | |
| von Willebrand factor + H2O | cleavage of the Tyr1605-Met(O)1606 peptide bond by ADAMTS13 | Homo sapiens | von Willebrand factor fragments | - |
? | |
| VWFA2 peptide + H2O | A2 domain fragment of von Willebrand factor, cleavage of oxidized or nonoxidized VWFA2 peptide by ADAMTS13, cleavage of the Tyr1605-Met(O)1606 peptide bond by ADAMTS13, overview | Homo sapiens | VWFA2 peptide fragments | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS13 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | reactive oxygen species released by activated neutrophils have a prothrombotic effect, mediated in part by inhibition of VWF cleavage by ADAMTS13 | Homo sapiens |
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