Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PF-548 | selective inhibitor | Homo sapiens | |
PF-548 | selective inhibitor | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
membrane | - |
Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P78536 | - |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Mus musculus | - |
aorta | - |
Homo sapiens | - |
endothelial cell | - |
Mus musculus | - |
endothelial cell | - |
Homo sapiens | - |
smooth muscle cell | - |
Mus musculus | - |
smooth muscle cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
a disintegrin and metalloproteinase-17 | - |
Mus musculus |
a disintegrin and metalloproteinase-17 | - |
Homo sapiens |
ADAM17 | - |
Mus musculus |
ADAM17 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | in aneurysmal thoracic aorta from patients, the enzyme Is increased in tunica media and intima | up |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition prevents progression of aneurysmal growth. Enzyme deficiency in smooth muscle and endothelial cells is sufficient to suppress thoracic aortic aneurysm dilation markedly. Enzyme deficiency in smooth muscle cells prevented the contractile-to-synthetic phenotypic switching in these cells after TAA induction, preventing perivascular fibrosis, inflammation, and adverse aortic remodeling. Loss of enzyme in endothelial cells protects the integrity of the intimal barrier by preserving the adherens junction (vascular endothelial-cadherin) and tight junctions (junctional adhesion molecule-A and claudin) | Mus musculus |
malfunction | enzyme inhibition prevents progression of aneurysmal growth. Enzyme deficiency in smooth muscle and endothelial cells is sufficient to suppress thoracic aortic aneurysm dilation markedly. Enzyme deficiency in smooth muscle cells prevented the contractile-to-synthetic phenotypic switching in these cells after TAA induction, preventing perivascular fibrosis, inflammation, and adverse aortic remodeling. Loss of enzyme in endothelial cells protects the integrity of the intimal barrier by preserving the adherens junction (vascular endothelial-cadherin) and tight junctions (junctional adhesion molecule-A and claudin) | Homo sapiens |