Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9Z0F8 | - |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | in ADAM17 hypomorphic mice, in which ADAM17 expression is reduced by 90-95% compared with wild-type littermates, ADAM17 deficiency results in spleen and lymph node enlargement, as well as increased levels of Ag-specific class-switched Ig production following immunization with OVA together with anti-CD40 mAbs and polyinosinic-polycytidylic acid. The costimulatory ligand ICOS (ICOSL) is selectively downregulated on the surface of B cells in an ADAM17-specific manner | Mus musculus |