Application | Comment | Organism |
---|---|---|
medicine | ADAM17/TACE might be an important therapeutic target. The blocking of ADAM17/TACE expression and/or the evaluation and development of specific TACE inhibitors might have therapeutic potential even in later stages of cancer. Furthermore, ADAM17/TACE might be useful as a diagnostic marker of pancreatic cancer to distinguish between PDAC and chronic pancreatitis. Aberrant ADAM17/TACE expression might be a diagnostic and therapeutic target in human pancreatic ductal adenocarcinoma | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tumor necrosis factor-alpha protease inhibitor | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | ADAM17/TACE mRNA is expressed in 3 of 10 normal pancreatic tissues, 6 of 8 samples from patients with chronic pancreatitis | Homo sapiens | - |
pancreatic cancer cell line | ADAM17/TACE mRNA is expressed in 10 of 10 PDAC tissues. ADAM17/TACE mRNA expression is down-regulated in pancreatic cancer cells arrested in G2 -M phase. Critical involvement of ADAM17/TACE in the invasion behavior of pancreatic cancer cells | Homo sapiens | - |
pancreatic ductal adenocarcinoma cell | ADAM17/TACE mRNA is expressed in 10 of 10 PDAC tissues. ADAM17/TACE expression is a later event in progression of pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ADAM17/tumor necrosis factor-alpha (TNF-A)converting enzyme | - |
Homo sapiens |