Application | Comment | Organism |
---|---|---|
medicine | isolation of TACE facilitates the development of therapeutically useful inhibitors of TNF-alpha release | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
isolation of cDNA clones encoding TACE by PCR | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | - |
Homo sapiens | |
TAPI | hydroxamic acid-based broad-spectrum inhibitor of zinc metalloproteinases | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
85000 | - |
SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Homo sapiens | - |
human monocytic cell line THP-1 | - |
Mus musculus | - |
mouse | - |
Mus musculus | - |
strain 129, strain C57Bl/6 chimaera/ly9.l- | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | peripheral blood T-cells | Mus musculus | - |
blood | peripheral blood T-cells | Homo sapiens | - |
bone marrow | - |
Mus musculus | - |
bone marrow | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
brain | fetal brain | Mus musculus | - |
endothelium | - |
Mus musculus | - |
endothelium | - |
Homo sapiens | - |
heart | - |
Mus musculus | - |
kidney | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
lung | - |
Homo sapiens | - |
monocyte | - |
Mus musculus | - |
monocyte | - |
Homo sapiens | - |
muscle | - |
Homo sapiens | - |
muscle | skeletal muscle, smooth muscle cells | Mus musculus | - |
neutrophil | - |
Mus musculus | - |
ovary | - |
Mus musculus | - |
pancreas | - |
Mus musculus | - |
placenta | - |
Mus musculus | - |
prostate | - |
Mus musculus | - |
small intestine | - |
Mus musculus | - |
spleen | - |
Mus musculus | - |
testis | - |
Mus musculus | - |
thymus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
proTNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | release of membrane-bound TNF-alpha | ? | |
transforming growth factor alpha + H2O | - |
Mus musculus | ? | - |
? | |
transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? |