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Literature summary for 3.4.24.85 extracted from
- IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response (2002), Genes Dev., 16, 452-466.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATF6 + H2O | Cricetulus griseus | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cricetulus griseus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ovary cell line | CHO-K1 wild type and M19 S2P deficient cell lines | Cricetulus griseus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATF6 + H2O | cleavage in site-2 is required for induction of IRE1-alpha and ER-stress activated target genes | Cricetulus griseus | ? | - |
? | |
| ATF6 + H2O | - |
Cricetulus griseus | ? | - |
? | |
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