Literature summary for 3.4.24.82 extracted from

Fushimi, K.; Troeberg, L.; Nakamura, H.; Lim, N.H.; Nagase, H.
Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity (2008), J. Biol. Chem., 283, 6706-6716.

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Activating Compound

Activating Compound	Comment	Organism	Structure
C-terminal thrombospondin type I motif of ADAMTS-5	addition of the C-terminal thrombospondin type I motif of ADAMTS-5 to the C terminus of ADAMTS-4 increases the activity of ADAMTS-4 against aggrecan and fibromodulin severalfold	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK293-EBNA cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
heparin	0.1 mg/ml, selective inhibition of full-length ADAMTS-4	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
anti-FLAG M2-agarose column chromatography	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
aggrecan + H2O	-	Homo sapiens	fragments of aggrecan	-	?
fibromodulin + H2O	cleaves at the Tyr44-Ala45 bond	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
a disintegrin and metalloproteinase with thrombospondin motifs-4	-	Homo sapiens
ADAMTS-4	-	Homo sapiens
aggrecanase-1	-	Homo sapiens

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Release 2023.1 (January 2023)