Application | Comment | Organism |
---|---|---|
degradation | abrasion of cartilage aggrecan in rheumatoid arthritis and osteoarthritis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Saccharomyces cerevisiae and COS-7 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibitory effect of alpha1-antitrypsin | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
SDS-PAGE, active enzyme | Homo sapiens |
50000 | - |
SDS-PAGE, after incubation with alpha1-antitrypsin suggesting that there ADAMTS-4 has almost no proteolytic activity | Homo sapiens |
75000 | - |
SDS-PAGE, inactive full-length enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
articular cartilage | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aggrecan + H2O | - |
Homo sapiens | fragments of aggrecan | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS-4 | - |
Homo sapiens |
aggrecanase-1 | - |
Homo sapiens |