Literature summary for 3.4.24.82 extracted from

Behera, A.K.; Hildebrand, E.; Szafranski, J.; Hung, H.H.; Grodzinsky, A.J.; Lafyatis, R.; Koch, A.E.; Kalish, R.; Perides, G.; Steere, A.C.; Hu, L.T.
Role of aggrecanase 1 in Lyme arthritis (2006), Arthritis Rheum., 54, 3319-3329.

Search for more literature for 3.4.24.82

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	4.2fold enhanced expression during infection with Borrelia burgdorferi	Mus musculus
additional information	57fold enhanced expression during infection with Borrelia burgdorferi	Bos taurus
additional information	enhanced expression during late-stage infections with Borrelia burgdorferi	Homo sapiens

Application

Application	Comment	Organism
degradation	degradation of cartilage in late-stage Lyme arthritis	Mus musculus
degradation	degradation of cartilage in late-stage Lyme arthritis	Homo sapiens
degradation	degradation of cartilage in late-stage Lyme arthritis	Bos taurus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
40000	-	SDS-PAGE, activated ADAMTS-4	Homo sapiens
53000	-	SDS-PAGE, activated ADAMTS-4	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-
Homo sapiens	-	-	-
Mus musculus	-	-	-
Mus musculus C3H/HEN	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
articular cartilage	-	Bos taurus	-
chondrocyte	-	Homo sapiens	-
joint	-	Mus musculus	-
synovia	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
aggrecan + H2O	-	Mus musculus	fragments of aggrecan	-	?
aggrecan + H2O	-	Homo sapiens	fragments of aggrecan	-	?
aggrecan + H2O	-	Bos taurus	fragments of aggrecan	-	?
aggrecan + H2O	-	Mus musculus C3H/HEN	fragments of aggrecan	-	?

Synonyms

Synonyms	Comment	Organism
ADAMTS 4	-	Mus musculus
ADAMTS 4	-	Homo sapiens
ADAMTS 4	-	Bos taurus
aggrecanase 1	-	Mus musculus
aggrecanase 1	-	Homo sapiens
aggrecanase 1	-	Bos taurus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)