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Literature summary for 3.4.24.81 extracted from

  • Chaimowitz, N.S.; Martin, R.K.; Cichy, J.; Gibb, D.R.; Patil, P.; Kang, D.J.; Farnsworth, J.; Butcher, E.C.; McCright, B.; Conrad, D.H.
    A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture (2011), J. Immunol., 187, 5114-5122.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.81

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
 Mus musculus
-
germinal center
-
 Mus musculus
-
Peyer's patch
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein + H2O
-
 Mus musculus sAPP-alpha fragment of beta-amyloid precursor protein + C-terminal fragment of beta-amyloid precursor protein
-
 ?
Notch1 + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloproteinase 10
-
 Mus musculus
ADAM10
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus ADAM10 levels are significantly enhanced on germinal center B cells up

General Information

General Information Comment Organism
malfunction B-cell specific ADAM10 deficient mice have severely diminished primary and secondary responses after T-dependent immunization, display impaired germinal center formation, have fewer follicular T helper cells, decreased follicular dendritic cell networks, and altered chemokine expression in draining lymph nodes Mus musculus
physiological function ADAM10 is essential for the maintenance of lymphoid structure after antigen challenge Mus musculus