Protein Variants | Comment | Organism |
---|---|---|
additional information | a mutant chimeric variant of PAPP-A, which is replaced in part by PAPP-A2 sequences, retains functionality as a protease but is unable to bind surface-associated glycosaminoglycan and shows no macrophage association or internalization | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | surface association of PAPP-A accounts for its colocalization with activated macrophages in human atherosclerotic plaque, immunohistochemic analysis, overview | Homo sapiens | 9986 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
IGF-binding protein-4 + H2O | Homo sapiens | i.e. IGFBP-4 | ? | - |
? | |
additional information | Homo sapiens | activated macrophage regulation of PAPP-A expression, co-localization of macophages and PAPP-A is involved in development of vulnerable plaques, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IGF-binding protein-4 + H2O | i.e. IGFBP-4 | Homo sapiens | ? | - |
? | |
additional information | activated macrophage regulation of PAPP-A expression, co-localization of macophages and PAPP-A is involved in development of vulnerable plaques, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAPP-A | - |
Homo sapiens |
pregnancy-associated plasma protein-A | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |