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Literature summary for 3.4.24.75 extracted from

  • Tossavainen, H.; Raulinaitis, V.; Kauppinen, L.; Pentikaeinen, U.; Maaheimo, H.; Permi, P.
    Structural and functional insights into lysostaphin-substrate interaction (2018), Front. Mol. Biosci., 5, 60 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Staphylococcus simulans

Inhibitors

Inhibitors Comment Organism Structure
Zn2+ partial inhibition of enzyme activity is observed in the excess of zinc Staphylococcus simulans

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ suitable cofactor Staphylococcus simulans
Cu2+ suitable cofactor Staphylococcus simulans
Mn2+ weak cofactor Staphylococcus simulans
Zn2+ contains zinc Staphylococcus simulans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Staphylococcus aureus cell wall + H2O Staphylococcus simulans the enzyme shows selectivity toward pentaglycine bridges in Staphylococcus aureus cell wall ?
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus simulans P10547
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione Sepharose 4 column chromatography and Superdex 75 gel filtration Staphylococcus simulans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Staphylococcus aureus cell wall + H2O the enzyme shows selectivity toward pentaglycine bridges in Staphylococcus aureus cell wall Staphylococcus simulans ?
-
 ?