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Literature summary for 3.4.24.74 extracted from
- Intestinal epithelial cells exposed to Bacteroides fragilis enterotoxin regulates NF-kappaB activation and inflammatory responses through beta-catenin expression (2019), Infect. Immun., 87, e00312-19 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| E-cadherin + H2O | Bacteroides fragilis | the enzyme cleaves the extracellular domain of E-cadherin. Its cleavage then releases beta-catenin associated with the cytoplasmic domain of E-cadherin | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacteroides fragilis | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| E-cadherin + H2O | the enzyme cleaves the extracellular domain of E-cadherin. Its cleavage then releases beta-catenin associated with the cytoplasmic domain of E-cadherin | Bacteroides fragilis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Bacteroides fragilis enterotoxin | - |
Bacteroides fragilis |
| BFT | - |
Bacteroides fragilis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme can destroy the tight junctions in intestinal epithelium by cleaving E-cadherin, resulting in release of beta-catenin and loss of tight junctions. Intestinal epithelial cells exposed to bacteroides fragilis enterotoxin regulate nuclear factor-kappaB activation and inflammatory responses through beta-catenin expression | Bacteroides fragilis |
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Release 2023.1 (January 2023)
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