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Literature summary for 3.4.24.74 extracted from

  • Herrou, J.; Choi, V.M.; Bubeck Wardenburg, J.; Crosson, S.
    Activation Mechanism of the Bacteroides fragilis cysteine peptidase, fragipain (2016), Biochemistry, 55, 4077-4084 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.74

Activating Compound

Activating Compound Comment Organism Structure
fragipain the enzyme is synthesized as an inactive zymogen that consists of an N-terminal prodomain, a flexible linker, and a C-terminal catalytic domain. It is activated through cleavage of an arginine-containing site in its flexible linker by fragipain Bacteroides fragilis

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rosetta (DE3) pLysS cells Bacteroides fragilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
E-cadherin + H2O Bacteroides fragilis
-
 ?
-
 ?
VE-cadherin + H2O Bacteroides fragilis
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bacteroides fragilis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
E-cadherin + H2O
-
 Bacteroides fragilis ?
-
 ?
VE-cadherin + H2O
-
 Bacteroides fragilis ?
-
 ?

Synonyms

Synonyms Comment Organism
Bacteroides fragilis toxin
-
 Bacteroides fragilis
BFT
-
 Bacteroides fragilis