Literature summary for 3.4.24.71 extracted from

Smith, A.I.; Rajapakse, N.W.; Kleifeld, O.; Lomonte, B.; Sikanyika, N.L.; Spicer, A.J.; Hodgson, W.C.; Conroy, P.J.; Small, D.H.; Kaye, D.M.; Parkington, H.C.; Whisstock, J.C.; Kuruppu, S.
N-terminal domain of Bothrops asper myotoxin II enhances the activity of endothelin converting enzyme-1 and neprilysin (2016), Sci. Rep., 6, 22413 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
K49-P1-20	i.e. N-terminal domain of Bothrops asper myotoxin II, 2fold enhancement of enzyme activity (maximal stimulation with 0.0001 mg/ml), activation concentration 50 (AC50) is 0.00192 mM	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0164	-	amyloid beta 40	in the presence of K49-P1-20, at pH 6.3 and 37°C	Homo sapiens
0.0239	-	amyloid beta 40	in the absence of K49-P1-20, at pH 6.3 and 37°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P42892	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cerebrospinal fluid	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(2,4-dinitrophenyl)-OH + H2O	-	Homo sapiens	?	-	?
amyloid beta 40 + H2O	-	Homo sapiens	?	-	?
big endothelin (18-34) + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
ECE-1	-	Homo sapiens

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Release 2023.1 (January 2023)