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Literature summary for 3.4.24.71 extracted from
- Regulation of endothelin-converting enzyme-1 expression in human neuroblastoma cells (2006), Exp. Biol. Med., 231, 1048-1053.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | carbachol and phorbol 12-myristate 13-acetate reduce enzyme expression in neuroblastoma NB7 cells, only isozyme ECE-1c remains detectable, overview | Homo sapiens | |
| additional information | expression of ECE-1 is significantly reduced in the cortex of adult rats after 15 mins of global ischemia, and is also significantly reduced in the striatum of rats subjected to prenatal hypoxia | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
| membrane | - |
Rattus norvegicus | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid-beta peptide + H2O | Homo sapiens | degradation | ? | - |
? |  |
| amyloid-beta peptide + H2O | Rattus norvegicus | degradation | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isozymes ECE-1a-d | - |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | analysis of the levels of ECE-1 expression and distribution under normal and pathologic conditions of Alzheimer disease, overview | Homo sapiens | - |
| brain | analysis of the levels of ECE-1 expression and distribution under normal and pathologic conditions of Alzheimer disease, overview | Rattus norvegicus | - |
| additional information | expression of ECE-1 is significantly reduced in the cortex of adult rats after 15 mins of global ischemia, and is also significantly reduced in the striatum of rats subjected to prenatal hypoxia | Rattus norvegicus | - |
| NB7 cell | - |
Homo sapiens | - |
| neuroblastoma cell | primary | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid-beta peptide + H2O | degradation | Homo sapiens | ? | - |
? | |
| amyloid-beta peptide + H2O | degradation | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ECE-1 | - |
Homo sapiens |
| ECE-1 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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