BRENDA - Reference to 3.4.24.71; Id = 683434

additional information

carbachol and phorbol 12-myristate 13-acetate reduce enzyme expression in neuroblastoma NB7 cells, only isozyme ECE-1c remains detectable, overview

Homo sapiens

additional information

expression of ECE-1 is significantly reduced in the cortex of adult rats after 15 mins of global ischemia, and is also significantly reduced in the striatum of rats subjected to prenatal hypoxia

Rattus norvegicus

membrane

-

Rattus norvegicus

16020

-

membrane

-

Homo sapiens

16020

-

amyloid-beta peptide + H2O

Homo sapiens

degradation

?

-

?

amyloid-beta peptide + H2O

Rattus norvegicus

degradation

?

-

?

Homo sapiens

-

isozymes ECE-1a-d

-

Rattus norvegicus

-

brain

analysis of the levels of ECE-1 expression and distribution under normal and pathologic conditions of Alzheimer disease, overview

Homo sapiens

-

brain

analysis of the levels of ECE-1 expression and distribution under normal and pathologic conditions of Alzheimer disease, overview

Rattus norvegicus

-

additional information

expression of ECE-1 is significantly reduced in the cortex of adult rats after 15 mins of global ischemia, and is also significantly reduced in the striatum of rats subjected to prenatal hypoxia

Rattus norvegicus

-

NB7 cell

-

Homo sapiens

-

neuroblastoma cell

primary

Homo sapiens

-

amyloid-beta peptide + H2O

degradation

683434

Homo sapiens

?

-

?

amyloid-beta peptide + H2O

degradation

683434

Rattus norvegicus

?

-

?

ECE-1

-

Rattus norvegicus

ECE-1

-

Homo sapiens

additional information

carbachol and phorbol 12-myristate 13-acetate reduce enzyme expression in neuroblastoma NB7 cells, only isozyme ECE-1c remains detectable, overview

Homo sapiens

additional information

expression of ECE-1 is significantly reduced in the cortex of adult rats after 15 mins of global ischemia, and is also significantly reduced in the striatum of rats subjected to prenatal hypoxia

Rattus norvegicus

membrane

-

Rattus norvegicus

16020

-

membrane

-

Homo sapiens

16020

-

amyloid-beta peptide + H2O

Homo sapiens

degradation

?

-

?

amyloid-beta peptide + H2O

Rattus norvegicus

degradation

?

-

?

brain

analysis of the levels of ECE-1 expression and distribution under normal and pathologic conditions of Alzheimer disease, overview

Homo sapiens

-

brain

analysis of the levels of ECE-1 expression and distribution under normal and pathologic conditions of Alzheimer disease, overview

Rattus norvegicus

-

additional information

expression of ECE-1 is significantly reduced in the cortex of adult rats after 15 mins of global ischemia, and is also significantly reduced in the striatum of rats subjected to prenatal hypoxia

Rattus norvegicus

-

NB7 cell

-

Homo sapiens

-

neuroblastoma cell

primary

Homo sapiens

-

amyloid-beta peptide + H2O

degradation

683434

Homo sapiens

?

-

?

amyloid-beta peptide + H2O

degradation

683434

Rattus norvegicus

?

-

?

752491

Cho

Endothelin-converting enzyme- ...

Rattus norvegicus

Anim. Cells Sys.

23

170-175

2019

-

1

-

2

-

1

-

2

-

1

-

1

-

1

-

1

-

752727

Lu

Endothelin-converting enzyme- ...

Homo sapiens

Biochem. J.

476

513-533

2019

-

1

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

2

-

752412

Heyman

Cyclosporine A induces endoth ...

Rattus norvegicus

Acta Physiol. (Oxf.)

223

e13033

2018

-

1

-

4

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

755626

Wu

High endothelin-converting en ...

Homo sapiens

Tumor Biol.

39

1010428317725922

2017

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1

-

1

-

2

-

2

-

1

-

1

-

1

-

1

-

2

-

1

-

753826

Boratko

TIMAP-protein phosphatase 1-c ...

Homo sapiens

Int. J. Biochem. Cell Biol.

73

11-18

2016

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

755423

Smith

N-terminal domain of Bothrops ...

Homo sapiens

Sci. Rep.

6

22413

2016

1

-

2

-

2

-

1

-

3

-

1

-

1

-

2

-

1

-

3

-

733074

Sonawane

Structural analysis of membran ...

Homo sapiens

Amino Acids

47

543-559

2015

-

1

-

2

-

1

2

-

1

-

1

-

734428

Park

Substance P stimulates endothe ...

Homo sapiens

J. Invest. Dermatol.

135

551-559

2015

-

1

-

1

2

-

2

-

2

-

2

1

2

-

1

-

1

2

-

2

-

2

1

-

1

-

734268

Jensen

Endothelin-converting enzyme 1 ...

Homo sapiens

J. Biol. Chem.

289

20283-20294

2014

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1

-

1

-

2

-

1

-

2

-

3

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1

-

1

-

1

-

1

-

2

-

1

-

3

-

1

-

1

-

734370

Kido-Nakahara

Neural peptidase endothelin-co ...

Homo sapiens, Mus musculus

J. Clin. Invest.

124

2683-2695

2014

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2

-

4

-

2

-

6

-

3

-

2

-

4

-

2

-

4

-

2

-

3

-

2

-

2

-

734684

Kuruppu

Soluble and catalytically acti ...

Homo sapiens

Mol. Cell. Proteomics

13

1091-1094

2014

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1

-

1

-

2

-

2

-

2

1

2

-

1

-

1

-

2

-

2

1

-

735130

Whyteside

Endothelin-converting enzyme-1 ...

Homo sapiens

PLoS ONE

9

e83260

2014

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1

-

1

-

4

-

1

-

1

-

1

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4

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1

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2

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2

-

734021

Pacheco-Quinto

Endothelin-converting enzymes ...

Homo sapiens

J. Alzheimers Dis.

33

S101

2013

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1

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5

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7

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1

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1

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7

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2

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1

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5

-

7

-

1

-

7

-

734617

Tanneeru

-

Ligand-based drug design for h ...

Homo sapiens

Med. Chem. Res.

22

4401-4409

2013

-

38

-

1

-

1

-

1

-

2

-

38

-

1

-

1

-

720472

Hasdemir

Endothelin-Converting Enzyme-1 ...

Homo sapiens

Mol. Endocrinol.

26

681-695

2012

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1

-

1

-

2

-

1

-

2

-

1

-

2

-

1

-

2

-

1

-

733056

Khamaisi

Hyperinsulinemia increases pla ...

Rattus norvegicus

Am. J. Hypertens.

25

109-114

2012

-

2

-

5

-

1

-

5

-

1

-

1

-

718716

Raoch

Nitric oxide decreases the exp ...

Bos taurus

Arterioscler. Thromb. Vasc. Biol.

31

2577-2585

2011

-

4

-

1

-

1

-

1

-

1

-

1

-

720315

Pelayo

Endothelin-converting enzyme-1 ...

Mus musculus

J. Physiol.

589

5213-5230

2011

-

2

-

3

-

2

-

1

-

1

-

2

-

2

-

1

-

1

-

709470

Jullien

Phosphinic tripeptides as dual ...

Homo sapiens

J. Med. Chem.

53

208-220

2010

-

1

-

17

1

-

2

-

1

-

1

-

1

-

16

-

1

-

17

16

1

-

1

-

1

-

710094

Palmer

Endothelin-converting enzyme-1 ...

Homo sapiens

Neuropathol. Appl. Neurobiol.

36

487-497

2010

-

1

-

3

-

1

-

2

-

3

-

10

-

8

-

3

-

1

-

3

-

1

-

2

-

10

-

8

-

719207

Whyteside

ECE-1 influences prostate canc ...

Homo sapiens

Can. J. Physiol. Pharmacol.

88

850-854

2010

-

1

-

2

-

2

-

1

-

1

-

2

-

2

-

720290

Wang

Expression and functional prof ...

Homo sapiens

J. Neurochem.

115

47-57

2010

-

2

-

1

-

2

-

1

-

697033

Keeble

Re-sensitization of neuropepti ...

Homo sapiens

Br. J. Pharmacol.

156

728-729

2009

-

1

-

1

-

4

-

1

-

1

-

1

-

4

-

2

-

1

-

1

-

4

-

1

-

4

-

697034

Cattaruzza

Endothelin-converting enzyme 1 ...

Homo sapiens, Rattus norvegicus

Br. J. Pharmacol.

156

730-739

2009

-

1

-

2

-

4

-

1

-

4

-

2

-

1

-

2

-

4

-

697686

Peltonen

Increase in tissue endothelin- ...

Homo sapiens

Eur. Heart J.

30

242-249

2009

-

1

-

3

-

2

-

2

-

1

-

2

-

698259

Lee

Effects of the endothelin-conv ...

Mus musculus, Mus musculus C57BL/6

Inflamm. Bowel Dis.

15

1007-1013

2009

-

1

-

143

-

2

1

-

2

-

1

-

2

1

-

699415

Martinez-Miguel

Endothelin-converting enzyme-1 ...

Bos taurus, Homo sapiens, Mus musculus, Mus musculus C57/BL6J

J. Lipid Res.

50

364-375

2009

-

1

-

1

-

66

-

6

-

6

-

1

-

1

-

6

-

699564

Schulz

Structure of human endothelin- ...

Homo sapiens

J. Mol. Biol.

385

178-187

2009

-

1

-

1

-

1

-

2

-

1

-

1

-

1

2

-

1

-

1

-

1

-

1

-

1

-

1

-

709039

Cottrell

Endosomal endothelin-convertin ...

Homo sapiens, Mus musculus, Rattus norvegicus

J. Biol. Chem.

284

22411-22425

2009

-

1

-

1

-

5

-

9

3

-

6

-

3

-

6

-

3

-

1

-

1

-

5

-

9

3

-

6

-

6

-

8

-

709856

Jin

C-338A polymorphism of the end ...

Homo sapiens

Microvasc. Res.

78

128-131

2009

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

683416

Roosterman

Endothelin-converting enzyme-1 ...

Homo sapiens

Endocrinology

149

2200-2207

2008

-

2

-

1

-

3

-

1

-

2

-

2

1

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

683702

Suekane

Enhanced expressions of endoth ...

Homo sapiens

J. Clin. Biochem. Nutr.

42

126-132

2008

-

1

-

2

-

2

-

1

-

2

-

1

-

2

-

1

-

683837

Khamaisi

Diabetes and radiocontrast med ...

Rattus norvegicus

Kidney Int.

74

91-100

2008

1

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

695457

Khimji

Divergent transforming growth ...

Rattus norvegicus

Am. J. Pathol.

173

716-727

2008

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

1

-

697100

Rayhman

Small interfering RNA molecule ...

Homo sapiens

Cancer Res.

68

9265-9273

2008

-

1

-

1

-

1

-

2

-

2

-

1

-

2

-

1

-

1

-

1

-

2

-

1

-

701191

Cerdeira

Endothelin-converting enzyme i ...

Bos taurus, Cavia sp., Homo sapiens, Rattus norvegicus, Sus scrofa

Rev. Port. Cardiol.

27

385-408

2008

-

1

2

-

16

-

4

-

5

-

5

-

10

-

14

-

1

2

-

14

16

-

4

-

5

-

683318

Raoch

The peptidase inhibitor CGS-26 ...

Bos taurus

Br. J. Pharmacol.

152

313-322

2007

1

-

4

-

1

-

1

-

3

-

2

1

-

1

-

2

1

-

1

-

1

-

4

-

1

-

1

-

2

1

-

1

-

1

-

1

-

683321

Smollich

On the role of endothelin-conv ...

Homo sapiens

Breast Cancer Res. Treat.

106

361-369

2007

-

1

-

1

-

1

-

2

-

3

-

2

-

3

-

1

-

1

-

1

-

3

-

2

-

683474

Kuruppu

Characterisation of endothelin ...

Homo sapiens

FEBS Lett.

581

4501-4506

2007

-

2

-

4

1

-

1

-

2

-

1

-

2

-

2

1

-

1

-

2

-

4

1

-

1

-

1

-

2

-

1

-

1

-

683513

Massai

Endothelin-1 and endothelin-co ...

Homo sapiens

Histol. Histopathol.

22

1343-1354

2007

-

1

-

2

-

2

-

1

-

2

-

1

-

2

-

1

-

683696

Padilla

Endothelin-converting enzyme-1 ...

Homo sapiens

J. Cell Biol.

179

981-997

2007

-

1

-

1

-

3

1

-

4

-

1

-

1

-

5

-

2

-

1

-

1

-

3

1

-

4

-

1

-

5

-

683713

Hyndman

Endothelin and endothelin conv ...

Fundulus heteroclitus

J. Exp. Biol.

210

4286-4297

2007

1

-

1

-

1

-

3

-

3

-

1

-

2

-

1

-

1

-

1

-

3

-

1

-

683720

Iwase

Distribution of endothelin-con ...

Homo sapiens

J. Histochem. Cytochem.

55

1229-1235

2007

-

1

-

2

-

3

-

1

-

2

-

1

-

3

-

1

-

683965

Buehler

Risk of coronary artery diseas ...

Homo sapiens

Pharmacogenet. Genomics

17

77-83

2007

-

1

-

2

-

1

-

1

-

2

-

2

-

1

-

2

-

1

-

2

-

1

-

1

-

2

-

1

-

668981

Awano

Endothelin system in oral squa ...

Homo sapiens

Int. J. Cancer

118

1645-1652

2006

-

1

-

2

-

1

-

2

-

1

-

1

-

669533

Gokhale

Metallopeptide-promoted inacti ...

Homo sapiens

J. Biol. Inorg. Chem.

11

937-947

2006

-

4

-

3

-

1

-

1

-

1

-

1

-

1

4

1

-

1

-

669974

Hanessian

Design and synthesis of divers ...

Homo sapiens

J. Org. Chem.

71

2760-2778

2006

-

2

-

1

-

2

-

2

-

683434

Fisk

Regulation of endothelin-conve ...

Homo sapiens, Rattus norvegicus

Exp. Biol. Med.

231

1048-1053

2006

-

2

-

2

-

2

-

4

-

6

-

2

-

2

-

2

-

2

-

2

-

6

-

2

-

683435

Dawson

Expression and localization of ...

Homo sapiens

Exp. Biol. Med.

231

1106-1110

2006

-

2

-

2

-

9

-

2

-

2

-

9

-

683437

Jafri

Phosphorylation of endothelin ...

Homo sapiens

Exp. Biol. Med.

231

713-717

2006

-

5

1

-

3

-

1

-

2

-

5

1

-

1

-

683438

Hunter

Expression and localization of ...

Homo sapiens

Exp. Biol. Med.

231

718-722

2006

-

2

1

-

1

-

2

-

4

-

2

-

2

-

2

1

-

1

-

4

-

2

-

683439

Klipper

Identification of a novel alte ...

Homo sapiens

Exp. Biol. Med.

231

723-728

2006

-

1

-

2

-

2

-

1

-

1

-

2

-

1

-

2

-

1

-

1

-

683440

Jackson

Expression and localization of ...

Homo sapiens

Exp. Biol. Med.

231

794-801

2006

-

1

-

1

-

2

-

4

-

2

-

2

-

1

-

1

-

4

-

2

-

683628

Eckman

Regulation of steady-state bet ...

Mus musculus

J. Biol. Chem.

281

30471-30478

2006

-

1

-

1

-

4

-

2

-

2

-

1

-

2

-

1

-

1

-

1

-

4

-

2

-

1

-

2

-

683725

Shirai

Expression of endothelin-conve ...

Homo sapiens

J. Hypertens.

24

711-721

2006

-

1

-

3

-

1

-

1

-

2

-

1

-

1

-

1

-

683918

Daray

Involvement of endothelial thr ...

Homo sapiens

Naunyn Schmiedebergs Arch. Pharmacol.

373

367-375

2006

-

1

-

1

-

2

-

1

-

2

-

1

-

1

-

1

-

2

-

684002

Choi

PKCepsilon increases endotheli ...

Homo sapiens, Mus musculus

Proc. Natl. Acad. Sci. USA

103

8215-8220

2006

2

-

2

-

2

-

2

-

4

-

9

-

4

-

4

2

-

2

-

2

-

2

-

2

-

2

-

9

-

4

-

2

-

2

-

667961

Brands

Novel, selective indole-based ...

Homo sapiens

Bioorg. Med. Chem. Lett.

15

4201-4205

2005

-

32

-

1

-

2

-

33

-

33

32

-

669782

Berger

Endothelin-converting enzyme-1 ...

Homo sapiens

J. Med. Chem.

48

483-498

2005

-

10

-

2

-

2

-

2

-

10

-

10

-

2

-

669970

Dibas

Characterization of endothelin ...

Homo sapiens

J. Ocul. Pharmacol. Ther.

21

196-204

2005

-

4

-

1

-

2

-

4

-

2

-

4

-

1

-

4

-

669569

Trapani

-

CGS 35601 and its orally activ ...

Homo sapiens

J. Cardiovasc. Pharmacol.

44

S211-S215

2004

-

1

-

2

-

1

-

2

-

1

-

1

-

1

2

-

670866

Klipper

Characterization of endothelin ...

Homo sapiens

Reproduction

128

463-473

2004

-

2

-

1

-

1

-

2

-

1

-

1

-

653706

Bur

A three-dimensional model of e ...

Homo sapiens

Protein Eng.

14

337-341

2001

-

1

-

1

-

1

-

1

-

2

-

1

5

-

1

-

1

-

1

-

1

-

1

-

649885

Cronin

Do the structures of big ET-1 ...

Homo sapiens

Biochemistry

38

1721-1726

1999

-

1

-

1

-

2

-

2

-

1

-

2

-

649414

Ahn

Soluble human endothelin-conve ...

Homo sapiens

Arch. Biochem. Biophys.

359

258-268

1998

1

-

1

-

6

-

3

1

-

3

-

1

-

1

-

2

1

3

-

3

2

-

1

-

1

-

6

-

6

-

3

1

-

1

-

1

-

2

1

-

3

2

-

651242

Hasegawa

Purification of a novel endoth ...

Bos taurus

FEBS Lett.

428

304-308

1998

-

2

1

-

1

-

3

-

1

-

1

-

3

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

652710

Wallace

Design and synthesis of potent ...

Homo sapiens

J. Med. Chem.

41

1513-1523

1998

-

1

-

28

-

1

-

2

-

2

-

2

-

1

-

28

-

1

-

2

-

651235

Korth

Construction, expression and c ...

Homo sapiens

FEBS Lett.

417

365-370

1997

4

-

1

-

4

-

1

-

2

1

-

2

-

2

1

3

-

4

-

1

-

4

-

1

-

2

1

-

2

1

-

31469

Shimada

Cloning and functional express ...

Rattus norvegicus

J. Biol. Chem.

269

18275-18278

1994

-

1

-

2

-

1

2

-

2

-

1

-

2

-

1

-

1

-

1

-

2

-

1

2

-

1

-

2

-

1

-

31470

Xu

ECE-1: a membrane-bound metall ...

Bos taurus

Cell

78

473-485

1994

-

1

-

5

-

1

-

2

-

1

-

1

-

3

-

6

1

-

1

-

1

-

1

-

5

-

1

-

2

-

1

-

3

-

6

1

-

1

-

31468

Takahashi

Purification and characterizat ...

Rattus norvegicus

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21394-21398

1993

-

4

3

2

1

2

1

-

3

-

1

-

2

1

-

5

1

-

1

-

1

-

4

-

3

2

1

2

1

-

1

-

2

1

-

5

1

-

1

-

Regulation of endothelin-converting enzyme-1 expression in human neuroblastoma cells

Data extracted from this reference: