Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | proteasome blockade, regardless of the inhibitor used, e.g. proteasome inhibitor I, MG-132, lactacystin, or bortezomib, decreases the production of type I collagen and TIMP-1 and up-regulates that of MMP-1, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Tissue inhibitor of metalloproteinase-1 | TIMP-1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen I + H2O | Homo sapiens | degradation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | dermal, quantitative MMP-1 expression analysis by RT-PCR | Homo sapiens | - |
skin | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
quantitative MMP-1 expression analysis by RT-PCR | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen I + H2O | degradation | Homo sapiens | ? | - |
? | |
collagen I + H2O | degradation, calf skin substrate | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-1 | - |
Homo sapiens |
MMP-1 | - |
Homo sapiens |