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Literature summary for 3.4.24.69 extracted from

  • Seki, H.; Xue, S.; Hixon, M.; Pellett, S.; Remeš, M.; Johnson, E.; Janda, K.
    Toward the discovery of dual inhibitors for botulinum neurotoxin A: Concomitant targeting of endocytosis and light chain protease activity (2015), Chem. Commun. (Camb. ), 51, 6226-6229.
    View publication on PubMed
Search for more literature for 3.4.24.69

Inhibitors

Inhibitors Comment Organism Structure
3'-O-ethyl-dynasore
-
 Clostridium botulinum
3-hydroxy-N'-[(E)-(2-hydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
-
 Clostridium botulinum
3-hydroxy-N'-[(E)-(3,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide competitive inhibition Clostridium botulinum
3-hydroxy-N'-[(E)-(3-hydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
-
 Clostridium botulinum
3H-dynasore
-
 Clostridium botulinum
3H-dyngo-4a
-
 Clostridium botulinum
chicoric acid iso-propyl ester competitive partial inhibition Clostridium botulinum
dynasore
-
 Clostridium botulinum
Dyngo-4a endocytic inhibitor of BoNT/A neurotoxicity through dynamin inhibition, competitive inhibition. Complete inhibition of the BoNT/A light chain at 0.02 mM Clostridium botulinum
lomofungin
-
 Clostridium botulinum
N'-[(E)-(2,4,5-trihydroxyphenyl)methylidene]benzohydrazide
-
 Clostridium botulinum
N'-[(E)-(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
-
 Clostridium botulinum

Organism

Organism UniProt Comment Textmining
Clostridium botulinum A5HZZ9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SNAPtide + H2O
-
 Clostridium botulinum ?
-
 ?

Synonyms

Synonyms Comment Organism
BoNT/A
-
 Clostridium botulinum
botulinum neurotoxin a
-
 Clostridium botulinum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00032
-
 Dyngo-4a pH and temperature not specified in the publication Clostridium botulinum
0.00046
-
 3-hydroxy-N'-[(E)-(3,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide pH and temperature not specified in the publication Clostridium botulinum
0.0018
-
 chicoric acid iso-propyl ester pH and temperature not specified in the publication Clostridium botulinum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00194
-
 pH and temperature not specified in the publication Clostridium botulinum 3-hydroxy-N'-[(E)-(3,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
0.00625
-
 pH and temperature not specified in the publication Clostridium botulinum N'-[(E)-(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
0.0293
-
 pH and temperature not specified in the publication Clostridium botulinum dynasore
0.04
-
 IC50 above 0.04 mM, pH and temperature not specified in the publication Clostridium botulinum 3-hydroxy-N'-[(E)-(2-hydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
0.04
-
 IC50 above 0.04 mM, pH and temperature not specified in the publication Clostridium botulinum N'-[(E)-(2,4,5-trihydroxyphenyl)methylidene]benzohydrazide
0.04
-
 IC50 above 0.04 mM, pH and temperature not specified in the publication Clostridium botulinum 3'-O-ethyl-dynasore
0.04
-
 IC50 above 0.04 mM, pH and temperature not specified in the publication Clostridium botulinum 3H-dyngo-4a
0.04
-
 IC50 above 0.04 mM, pH and temperature not specified in the publication Clostridium botulinum 3H-dynasore
0.04
-
 IC50 above 0.04 mM, pH and temperature not specified in the publication Clostridium botulinum 3-hydroxy-N'-[(E)-(3-hydroxyphenyl)methylidene]naphthalene-2-carbohydrazide