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Literature summary for 3.4.24.69 extracted from

  • Coffield, J.A.; Yan, X.
    Neuritogenic actions of botulinum neurotoxin A on cultured motor neurons (2009), J. Pharmacol. Exp. Ther., 330, 352-358.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.69

Inhibitors

Inhibitors Comment Organism Structure
Triticum vulgaris lectin a known competitive antagonist of BoNT, inhibits the activation of neurit outgrowth by BoNT/A Clostridium botulinum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
SNAP-25 + H2O Clostridium botulinum i.e. 25-kDa synaptosomal-associated protein, substrate of BoNT/A ?
-
 ?

Organism

Organism UniProt Comment Textmining
Clostridium botulinum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SNAP-25 + H2O i.e. 25-kDa synaptosomal-associated protein, substrate of BoNT/A Clostridium botulinum ?
-
 ?

Synonyms

Synonyms Comment Organism
BoNT serotype A
-
 Clostridium botulinum
BoNT/A
-
 Clostridium botulinum
botulinum neurotoxin a
-
 Clostridium botulinum

General Information

General Information Comment Organism
physiological function BoNTs are extremely potent neuromuscular poisons that act through soluble N-ethylmaleimide-sensitive factor attachment protein receptor, SNARE, protein cleavage to inhibit neurotransmitter release. Ability of BoNT/A to eliminate localized transmitter and to induce nerve outgrowth.. BoNT/A potently stimulates neuritogenesis at concentrations as low as 0.01 nM in primary cultures enriched with motor neurons isolated from embryonic mouse spinal cord. Presence or absence of SNAP-25 cleavage by BoNT/A is not a determinant factor in BoNT/A-induced neuritogenesis Clostridium botulinum