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Literature summary for 3.4.24.64 extracted from

  • Burkhart, J.M.; Taskin, A.A.; Zahedi, R.P.; Voegtle, F.N.
    Quantitative profiling for substrates of the mitochondrial presequence processing protease reveals a set of nonsubstrate proteins increased upon proteotoxic stress (2015), J. Proteome Res., 14, 4550-4563 .
    View publication on PubMed
Search for more literature for 3.4.24.64

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P10507 AND P11914 P10507: mitochondrial-processing peptidase subunit beta (MAS1), P11914: mitochondrial-processing peptidase subunit alpha (MAS2)
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Saccharomyces cerevisiae ATCC 204508 P10507 AND P11914 P10507: mitochondrial-processing peptidase subunit beta (MAS1), P11914: mitochondrial-processing peptidase subunit alpha (MAS2)
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information quantitative ChaFRADIC (charge-based fractional diagonal chromatography) analysis identifies 66 novel substrate proteins, which allow refinement of the MPP cleavage site establishing R2 as a major determinant of mitochondrial processing protease recognition and processing. Proteins that do not posses a presequence are not substrates Saccharomyces cerevisiae ?
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additional information quantitative ChaFRADIC (charge-based fractional diagonal chromatography) analysis identifies 66 novel substrate proteins, which allow refinement of the MPP cleavage site establishing R2 as a major determinant of mitochondrial processing protease recognition and processing. Proteins that do not posses a presequence are not substrates Saccharomyces cerevisiae ATCC 204508 ?
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preprotein Din7 + H2O
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 Saccharomyces cerevisiae presequence + protein Din7
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preprotein Din7 + H2O
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 Saccharomyces cerevisiae ATCC 204508 presequence + protein Din7
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preprotein Mrx8 + H2O
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 Saccharomyces cerevisiae presequence + protein Mrx8
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preprotein Mrx8 + H2O
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 Saccharomyces cerevisiae ATCC 204508 presequence + protein Mrx8
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preprotein Yhb1 + H2O
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 Saccharomyces cerevisiae presequence + protein Yhb1
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preprotein Yhb1 + H2O
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 Saccharomyces cerevisiae ATCC 204508 presequence + protein Yhb1
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Synonyms

Synonyms Comment Organism
mitochondrial processing protease
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 Saccharomyces cerevisiae
MPP
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction analysis of the mas1 mutant (temperature-sensitive mas1 mutant strain in which mitochondrial processing protease (MPP) is inactive when the cells are shifted to growth at nonpermissive temperature (37 °C)) reveales an increase in protein levels of nonprocessed mitochondrial proteins as well as an elevated membrane potential and increased oxygen consumption in mas1 mitochondria upon growth at nonpermissive temperature is observed. These findings might point toward a response in mas1 cells triggered to counterbalance the proteotoxic stress induced by MPP dysfunction Saccharomyces cerevisiae