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Literature summary for 3.4.24.42 extracted from

  • Serrano, S.M.; Wang, D.; Shannon, J.D.; Pinto, A.F.; Polanowska-Grabowska, R.K.; Fox, J.W.
    Interaction of the cysteine-rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor-mediated platelet aggregation (2007), FEBS J., 274, 3611-3621.
    View publication on PubMed
Search for more literature for 3.4.24.42

Inhibitors

Inhibitors Comment Organism Structure
catrocollastatin C
-
 Crotalus atrox
additional information the isolated recombinant cysteine-rich domain of atrolysin A does not inhibit full-length atrolysin activity, overview Crotalus atrox

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Crotalus atrox
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc metalloprotease Crotalus atrox

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
von Willebrand factor + H2O Crotalus atrox VWF is a large, multidomain glycoprotein present in human blood and in the secretory granules of endothelial cells and platelets ?
-
 ?

Organism

Organism UniProt Comment Textmining
Crotalus atrox
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Crotalus atrox
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
von Willebrand factor + H2O VWF is a large, multidomain glycoprotein present in human blood and in the secretory granules of endothelial cells and platelets Crotalus atrox ?
-
 ?
von Willebrand factor + H2O i.e. VWF, is a large, multidomain glycoprotein, atrolysin C does not require specific interaction with the VWA1 domain and likely cleaves VWF in a nonlocalized manner, cleavage in sequences MSMG-/-VSG, MSMG(C)V-/-G, LVPDS-/-H, and MSMG(C)VSG, after the D domain and the cystine knot-like domain, atrolysin C cleaves VWF at widely distributed sites identified next to VWD3 and VWD4 domains, overview Crotalus atrox ?
-
 ?

Synonyms

Synonyms Comment Organism
PI metalloproteinase
-
 Crotalus atrox

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Crotalus atrox

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Crotalus atrox