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Literature summary for 3.4.24.29 extracted from

  • Kantyka, T.; Pyrc, K.; Gruca, M.; Smagur, J.; Plaza, K.; Guzik, K.; Zeglen, S.; Ochman, M.; Potempa, J.
    Staphylococcus aureus proteases degrade lung surfactant protein a potentially impairing innate immunity of the lung (2013), J. Innate Immun., 5, 251-260.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Staphylococcus aureus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metalloprotease Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification required for enzyme activation Staphylococcus aureus

Purification (Commentary)

Purification (Comment) Organism
native enzyme by anion exchange chromatography Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information pulmonary surfactant protein-A from human host lung is no substrate for aureolysin from Staphylococcus aureus, but for staphylopain A, EC 3.4.22.48 Staphylococcus aureus ?
-
 ?

General Information

General Information Comment Organism
physiological function the enzyme interacts with the host tissue components in vitro to modulate host defense mechanisms and likely increase bacterial survival, but is not involved in the breakdown of first line of innate immune defense agent, pulmonary surfactant protein-A, of human host lung cells Staphylococcus aureus