Literature summary for 3.4.24.27 extracted from

Chura-Chambi, R.M.; Fraga, T.R.; da Silva, L.B.; Yamamoto, B.B.; Isaac, L.; Barbosa, A.S.; Morganti, L.
Leptospira interrogans thermolysin refolded at high pressure and alkaline pH displays proteolytic activity against complement C3 (2018), Biotechnol. Rep., 19, e00266 .

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Cloned(Commentary)

Cloned (Comment)	Organism
an efficient method of production of enzymatically active thermolysin by refolding the protein expressed as inclusion bodies in Escherichia coli. Association of high pressure and alkaline pH is very efficient for solubilization	Leptospira interrogans serovar Copenhageni

Organism

Organism	UniProt	Comment	Textmining
Leptospira interrogans serovar Copenhageni	Q72M68	-	-
Leptospira interrogans serovar Copenhageni Fiocruz L1-130	Q72M68	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	thermolysin encoded by LIC13322 has a signal peptide for secretion, a fungalin/thermolysin propeptide (FTP) domain, a propeptide (PepSY) domain, and a catalytic domain M4 that includes peptidase_M4 and peptidase_M4_C	Leptospira interrogans serovar Copenhageni

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
complement component C3 + H2O	proteolytic activity of thermolysin against C3 is time and dose-dependent	Leptospira interrogans serovar Copenhageni	?	-	?
complement component C3 + H2O	proteolytic activity of thermolysin against C3 is time and dose-dependent	Leptospira interrogans serovar Copenhageni Fiocruz L1-130	?	-	?

Synonyms

Synonyms	Comment	Organism
LIC13322	-	Leptospira interrogans serovar Copenhageni

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Release 2023.1 (January 2023)