Inhibitors | Comment | Organism | Structure |
---|---|---|---|
TIMP-2 | specific for MMP-2 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | extracellular matrix | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens | |
Zn2+ | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
62000 | - |
x * 72000, latent MMP-2, SDS-PAGE, x * 62000, activ MMP-2, SDS-PAGE | Homo sapiens |
72000 | - |
x * 72000, latent MMP-2, SDS-PAGE, x * 62000, activ MMP-2, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen type IV + H2O | Homo sapiens | - |
? | - |
? | |
Gelatin + H2O | Homo sapiens | - |
? | - |
? | |
additional information | Homo sapiens | the enzyme degrades proteins of the extracellular matrix in the uterus and might be involved in the growth of leiomyoma and corresponding myometrium, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
MMP-2 is a constitutive enzyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endometrium | - |
Homo sapiens | - |
myometrium | derived from premenopausal women aged 45-55 years who underwent total abdominal hysterectomy | Homo sapiens | - |
uterine leiomyoma cell | fibroids of different size show equal MMP-2 activity | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
enzyme activity in leiomyoma and myometrium, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen type IV + H2O | - |
Homo sapiens | ? | - |
? | |
Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
Gelatin + H2O | gelatin zymography using porcine gelatin type A | Homo sapiens | ? | - |
? | |
additional information | the enzyme degrades proteins of the extracellular matrix in the uterus and might be involved in the growth of leiomyoma and corresponding myometrium, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 72000, latent MMP-2, SDS-PAGE, x * 62000, activ MMP-2, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |