Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | binding of matrilysin-1 to epithelial cells via cholesterol sulfate, protamine or heparin promotes its activity and renders the enzyme resistant to TIMP-2, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
MMPI-II | a small synthetic inhibitor of 514 Da | Homo sapiens | |
TIMP-2 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
intracellular | pro-MMP-7 is diffusely distributed in epithelial cells of the endometrium, while the mature enzyme is located at the plasma membrane | Homo sapiens | 5622 | - |
plasma membrane | pro-MMP-7 is diffusely distributed in epithelial cells of the endometrium, while the mature enzyme is located at the plasma membrane | Homo sapiens | 5886 | - |
soluble | pro-MMP-7 is diffusely distributed in epithelial cells of the endometrium, while the mature enzyme is located at the plasma membrane | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | MMP-7 is a zinc-dependent endoproteinase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | matrilysin-1 modulates crucial biological events by processing many epithelial cell surface-associated effectors, MMP-7 binds to epithelial and Ishikawa cells via cholesterol sulfate, protamine, or heparin, cell binding mechanism, MMP-7 can directly interact with the cells, without proMMP-7 having to bind first to the cell surface for local activation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09237 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endometrium | - |
Homo sapiens | - |
epithelial cell | pro-MMP-7 is diffusely distributed in epithelial cells of the endometrium, while the mature enzyme is located at the plasma membrane | Homo sapiens | - |
Ishikawa cell | endometrial carcinoma-derived cell line | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
quantitative determination of binding sites for MMP-7 on epithelial cells and Ishikawa cells, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
casein + H2O | fluorescence-labeled substrate | Homo sapiens | ? | - |
? | |
additional information | matrilysin-1 modulates crucial biological events by processing many epithelial cell surface-associated effectors, MMP-7 binds to epithelial and Ishikawa cells via cholesterol sulfate, protamine, or heparin, cell binding mechanism, MMP-7 can directly interact with the cells, without proMMP-7 having to bind first to the cell surface for local activation, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrilysin-1 | - |
Homo sapiens |
Matrix metalloproteinase-7 | - |
Homo sapiens |
MMP-7 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000009 | - |
TIMP-2 | pH 7.4, 37°C, soluble enzyme | Homo sapiens | |
0.000027 | - |
MMPI-II | pH 7.4, 37°C, soluble enzyme | Homo sapiens | |
0.000053 | - |
MMPI-II | pH 7.4, 37°C, membrane-bound enzyme | Homo sapiens | |
0.000064 | - |
TIMP-2 | pH 7.4, 37°C, membrane-bound enzyme | Homo sapiens |