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Literature summary for 3.4.24.23 extracted from

  • Oneda, H.; Inouye, K.
    Interactions of human matrix metalloproteinase 7 (matrilysin) with the inhibitors thiorphan and R-94138 (2001), J. Biochem., 129, 429-435.
    View publication on PubMed

Application

Application Comment Organism
medicine development of effective inhibitors useful for cancer therapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
recombinant pro-matrilysin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition with phosphoramidon Homo sapiens
R-94138
-
Homo sapiens
thiorphan
-
Homo sapiens
Zincov
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-L-Ala-L-Arg-NH2 + H2O MOCAc-PLGL(Dpa)AR, Lot 480429 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
matrilysin
-
Homo sapiens
Matrix metalloproteinase 7
-
Homo sapiens
MMP-7
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
4 10
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0105
-
R-94138 pH 7.5, 25°C Homo sapiens
0.0112
-
thiorphan pH 7.5, 25°C Homo sapiens
0.015
-
thiorphan pH 7.5, 37°C Homo sapiens