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Literature summary for 3.4.24.21 extracted from
- Astacin gene family of metalloproteinases in planarians structural organization and tissue distribution (2018), Gene Expr. Patterns, 28, 77-86 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| astacins genomic organization, phylogenetic analysis | Schmidtea mediterranea |
| astacins genomic organization, phylogenetic analysis, enzyme expression analysis during regeneration, overview | Schmidtea mediterranea |
| astacins genomic organization, phylogenetic analysis, enzyme expression analysis in tissues and during regeneration | Schmidtea mediterranea |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Schmidtea mediterranea | - |
- |
| additional information | the N-terminal hydrophobic signal peptide directs the proteins into the endoplasmic reticulum during biosynthesis | Schmidtea mediterranea | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schmidtea mediterranea | - |
- |
- |
| Schmidtea mediterranea | A0A060Q6V2 | - |
- |
| Schmidtea mediterranea | A0A060Q6Y6 | - |
- |
| Schmidtea mediterranea | A0A060Q714 | - |
- |
| Schmidtea mediterranea | A0A060Q715 | - |
- |
| Schmidtea mediterranea | A0A060Q750 | - |
- |
| Schmidtea mediterranea | A0A060Q785 | - |
- |
| Schmidtea mediterranea | A0A060Q786 | - |
- |
| Schmidtea mediterranea | I1ZIC3 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gastrodermis | - |
Schmidtea mediterranea | - |
| additional information | eight astacins with a minimal structure (a signal peptide, an activation domain and a Zn-binding catalytic domain), that are colocalized in large cells organized in a peculiar, not yet morphologically characterized, two-ring-shaped structure located in the middle of the body. A single astacin Smed-ast-8, characterized by a ShK toxin domain in its C-terminal region, has been found to be produced in gastrodermal cells. Smed-ast-1 almost completely colocalizes with Smed-ast-2, Smedast-3, Smed-ast-4, Smed-ast-5, Smed-ast-6, Smed-ast-7 and Smed-ast-9. Planarian astacins are exclusive for post-mitotic differentiated cells | Schmidtea mediterranea | - |
| neoblast | - |
Schmidtea mediterranea | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | domain organization of astacins, overview | Schmidtea mediterranea |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ast1 | - |
Schmidtea mediterranea |
| Ast2 | - |
Schmidtea mediterranea |
| Ast3 | - |
Schmidtea mediterranea |
| Ast4 | - |
Schmidtea mediterranea |
| Ast5 | - |
Schmidtea mediterranea |
| Ast6 | - |
Schmidtea mediterranea |
| Ast7 | - |
Schmidtea mediterranea |
| Ast9 | - |
Schmidtea mediterranea |
| Smed-ast-1 | - |
Schmidtea mediterranea |
| Smed-ast-2 | - |
Schmidtea mediterranea |
| Smed-ast-3 | - |
Schmidtea mediterranea |
| Smed-ast-4 | - |
Schmidtea mediterranea |
| Smed-ast-5 | - |
Schmidtea mediterranea |
| Smed-ast-6 | - |
Schmidtea mediterranea |
| Smed-ast-7 | - |
Schmidtea mediterranea |
| Smed-ast-9 | - |
Schmidtea mediterranea |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | structural organization of the astacin-like gene family in planarians, overview. All members of the astacin family are characterized by two key elements: the 18-amino acid zinc-binding motif (HEXXHXXGFXHEXXRXDR), and the methionine-turn (Met-turn) sequence SXMHY | Schmidtea mediterranea |
| physiological function | the astacin gene family of metalloproteinases in planarians, good candidate enzymes for generating dynamicity in the extracellular matrix. Astacins are secreted and membrane-bound metzincin metallopeptidases widespread among different animal phyla and involved in various physiological processes, including digestion, extracellular matrix (ECM) remodeling, morphogenesis, hatching, tissue remodeling, and differentiation | Schmidtea mediterranea |
| physiological function | the astacin gene family of metalloproteinases in planarians, good candidate enzymes for generating dynamicity in the extracellular matrix. Astacins are secreted and membrane-bound metzincin metallopeptidases widespread among different animal phyla and involved in various physiological processes, including digestion, extracellular matrix (ECM) remodeling, morphogenesis, hatching, tissue remodeling, and differentiation. Morphogenesis of the two-ring-shaped structure by visualization of Smed-ast-2 expression during regeneration. Smed-mmp1 and Smed-mmp2 are specialized in storage and secretion of extracellular matrix degrading enzymes | Schmidtea mediterranea |
| physiological function | the astacin gene family of metalloproteinases in planarians, good candidate enzymes for generating dynamicity in the extracellular matrix. Astacins are secreted and membrane-bound metzincin metallopeptidases widespread among different animal phyla and involved in various physiological processes, including digestion, extracellular matrix (ECM) remodeling, morphogenesis, hatching, tissue remodeling, and differentiation. Smed-mmp1 and Smed-mmp2 are specialized in storage and secretion of extracellular matrix degrading enzymes | Schmidtea mediterranea |
| physiological function | the astacin gene family of metalloproteinases in planarians, good candidate enzymes for generating dynamicity in the extracellular matrix. Astacins are secreted and membrane-bound metzincin metallopeptidases widespread among different animal phyla and involved in various physiological processes, including digestion, extracellular matrix (ECM) remodeling, morphogenesis, hatching, tissue remodeling, and differentiation. The ast-8 expression in the digestive system is a feature typically conserved in genes encoding astacins with a ShToxin domain | Schmidtea mediterranea |
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Release 2023.1 (January 2023)
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