Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Homo sapiens | - |
- |
additional information | meprin alpha contains an additional inserted domain (I-domain), which is proteolytically cleaved by furin within the Golgi | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc-dependent metalloendoprotease | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | Homo sapiens | - |
? | - |
? | |
bradykinin + H2O | Homo sapiens | - |
? | - |
? | |
Collagen IV + H2O | Homo sapiens | - |
? | - |
? | |
Fibronectin + H2O | Homo sapiens | - |
? | - |
? | |
gastrin + H2O | Homo sapiens | - |
? | - |
? | |
laminin V + H2O | Homo sapiens | - |
? | - |
? | |
nidogen 1 + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16819 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | meprin alpha contains an additional inserted domain (I-domain), which is proteolytically cleaved by furin within the Golgi. Activation of meprin alpha by proteolytic cleavage through furin. Meprin alpha also contains a conserved sequence motif, which gives rise to enzymatic activation by tryptic serine proteases. Pancreatic trypsin performs this activation in the gut. Outside the intestinal tract, meprin alpha can be efficiently activated by plasmin. In the skin, maturation of meprin alpha is done by KLK5 only, not by other KLK proteases | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | - |
Homo sapiens | ? | - |
? | |
bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
Collagen IV + H2O | - |
Homo sapiens | ? | - |
? | |
Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
gastrin + H2O | - |
Homo sapiens | ? | - |
? | |
laminin V + H2O | - |
Homo sapiens | ? | - |
? | |
nidogen 1 + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | meprin alpha is the largest secreted protease known, forming complex homooligomers of molecular weights up to 6MDa | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
meprin alpha | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | meprin alpha belongs to the astacin family of zinc-endopeptidases and the metzincin superfamily, characterized by the conserved motif HExxHxxGxxHxxxRxDR | Homo sapiens |
physiological function | meprins cleave compounds of the extracellular matrix such as laminin-V, collagen IV, fibronectin or nidogen 1, but also growth factors, cytokines and peptide hormones, including bradykinin, angiotensins, and gastrin | Homo sapiens |