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Literature summary for 3.4.24.18 extracted from
- Membrane association and oligomeric organization of the alpha and beta subunits of mouse meprin A (1994), J. Biol. Chem., 269, 15388-15393.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | cell surface metalloproteinase, alphabeta-heterodimers firmly attached to brush border membrane, alpha2-homodimers only associated with membrane | Mus musculus | 16020 | - |
| membrane | cell surface metalloproteinase, alphabeta-heterodimers firmly attached to brush border membrane, alpha2-homodimers only associated with membrane | Rattus norvegicus | 16020 | - |
| membrane | renal brush border membrane | Mus musculus | 16020 | - |
| membrane | renal brush border membrane | Rattus norvegicus | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 69000 | - |
x * 69000 + x * 79000, mouse, deglycosylated alpha and beta-subunit, SDS-PAGE in the presence of 2-mercaptoethanol | Mus musculus |
| 69000 | - |
x * 69000 + x * 79000, mouse, deglycosylated alpha and beta-subunit, SDS-PAGE in the presence of 2-mercaptoethanol | Rattus norvegicus |
| 79000 | - |
x * 69000 + x * 79000, mouse, deglycosylated alpha and beta-subunit, SDS-PAGE in the presence of 2-mercaptoethanol | Mus musculus |
| 79000 | - |
x * 69000 + x * 79000, mouse, deglycosylated alpha and beta-subunit, SDS-PAGE in the presence of 2-mercaptoethanol | Rattus norvegicus |
| 86000 | - |
x * 86000, mouse, performic acid oxidized enzyme, sedimentation equilibrium centrifugation with 4 M guanidine-HCl | Mus musculus |
| 86000 | - |
x * 86000, mouse, performic acid oxidized enzyme, sedimentation equilibrium centrifugation with 4 M guanidine-HCl | Rattus norvegicus |
| 90000 | - |
x * 90000 + x * 110000, mouse, SDS-PAGE | Mus musculus |
| 90000 | - |
x * 90000 + x * 110000, mouse, SDS-PAGE | Rattus norvegicus |
| 110000 | - |
x * 90000 + x * 110000, mouse, SDS-PAGE | Mus musculus |
| 110000 | - |
x * 90000 + x * 110000, mouse, SDS-PAGE | Rattus norvegicus |
| 167000 | - |
mouse, native enzyme, sedimentation equilibrium centrifugation with 4 M guanidine-HCl | Mus musculus |
| 171000 | - |
mouse, SDS-PAGE, 3-20% gradient gel, non-reducing conditions | Mus musculus |
| 204000 | - |
mouse, alpha2 homodimer, SDS-PAGE, non-reducing conditions | Mus musculus |
| 224000 | - |
mouse, alphabeta homodimer, SDS-PAGE, non-reducing conditions | Mus musculus |
| 245000 | - |
mouse, PAGE in the presence of 4 M urea | Mus musculus |
| 250000 | - |
above, mouse, SDS-PAGE, 10% homogenous gel, non-reducing conditions | Mus musculus |
| 360000 | - |
mouse, sedimentation equilibrium centrifugation | Mus musculus |
| 495000 | - |
mouse, PAGE | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
Sprague Dawley | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | 30% oligosaccharides | Mus musculus |
| glycoprotein | 30% oligosaccharides | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Mus musculus | - |
| kidney | - |
Rattus norvegicus | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the basic covalently linked structure is a dimer | Mus musculus |
| More | the basic covalently linked structure is a dimer | Rattus norvegicus |
| More | beta-subunit is a type I transmembrane protein | Mus musculus |
| More | beta-subunit is a type I transmembrane protein | Rattus norvegicus |
| oligomer | x * 69000 + x * 79000, mouse, deglycosylated alpha and beta-subunit, SDS-PAGE in the presence of 2-mercaptoethanol | Mus musculus |
| oligomer | x * 69000 + x * 79000, mouse, deglycosylated alpha and beta-subunit, SDS-PAGE in the presence of 2-mercaptoethanol | Rattus norvegicus |
| oligomer | x * 86000, mouse, performic acid oxidized enzyme, sedimentation equilibrium centrifugation with 4 M guanidine-HCl | Mus musculus |
| oligomer | x * 86000, mouse, performic acid oxidized enzyme, sedimentation equilibrium centrifugation with 4 M guanidine-HCl | Rattus norvegicus |
| tetramer | x * 90000 + x * 110000, mouse, SDS-PAGE | Mus musculus |
| tetramer | x * 90000 + x * 110000, mouse, SDS-PAGE | Rattus norvegicus |
| tetramer | disulfide-bridged dimers (alpha2 or alphabeta) aggregate non-covalently to form higher MW complexes, predominantly tetramers | Mus musculus |
| tetramer | disulfide-bridged dimers (alpha2 or alphabeta) aggregate non-covalently to form higher MW complexes, predominantly tetramers | Rattus norvegicus |
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