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Literature summary for 3.4.24.17 extracted from
- A rationalization of the acidic pH dependence for stromelysin-1 (Matrix metalloproteinase-3) catalysis and inhibition (2000), J. Biol. Chem., 275, 11026-11033.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | MMP inhibitor development is the target of considerable effort within the pharmaceutical industry, MMP activity can contribute to the pathologies of cancer invasion and metastasis, arthritis, autoimmune disease, tissue ulceration, or cardiovascular disease | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| catalytic domain expressed in Escherichia coli | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| in complex with inhibitor | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| carboxylic acid diphenylpiperidine inhibitor | - |
Homo sapiens | |
| hydroxamic acid diphenylpiperidine inhibitor | - |
Homo sapiens | |
| hydroxamic acid substrate mimetic inhibitor | U24522 | Homo sapiens | |
| TIMP | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | calcium-dependent | Homo sapiens |  |
| Zn2+ | Glu202.zinc.H2O complex, zinc-dependent | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | degrading all of the major macromolecules of the extracellular matrix | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | degrading all of the major macromolecules of the extracellular matrix | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| matrix metalloproteinase-3 | - |
Homo sapiens |
| matrixin | - |
Homo sapiens |
| stromelysin-1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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