Cloned (Comment) | Organism |
---|---|
recombinant bovine ADAMTS-2 is produced in HEK 293-EBNA cells | Bos taurus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | three constructs coding for catalytically inactive ADAMTS-2 or for ADAMTS-2 lacking either the central or the C-terminal domains are created and used for stable transfection of HEK 293-EBNA cells. Results show that the catalytic activity of ADAMTS-2 is dispensable for antiangiogenic activity | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS-2 | - |
Bos taurus |
General Information | Comment | Organism |
---|---|---|
malfunction | an anti-tumoral activity is also observed when using cells expressing recombinant deleted forms of ADAMTS-2, including catalytically inactive enzyme | Bos taurus |
physiological function | ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule independently of its catalytic activity | Bos taurus |