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Literature summary for 3.4.24.11 extracted from

  • Sajid, M.; Isaac, R.E.
    Identification and properties of a neuropeptide-degrading endopeptidase (neprilysin) of Ascaris suum muscle (1995), Parasitology, 111, 599-608.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
phosphoramidon
-
Ascaris suum
SQ 28603
-
Ascaris suum
thiorphan
-
Ascaris suum

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral membrane protein Ascaris suum 16020
-

Organism

Organism UniProt Comment Textmining
Ascaris suum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle body wall musculature Ascaris suum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Ala2-Leu5-enkephalin + H2O i.e. Tyr-D-Ala-Gly-Phe-Leu Ascaris suum Tyr-D-Ala-Gly + Phe-Leu
-
?
pyroglutamyl-Leu-Asn-Phe-Thr-Pro-Asn-Trp-Gly-Thr-NH2 + H2O
-
Ascaris suum pyroglutamyl-Leu-Asn + Phe-Thr-Pro-ASn-Trp-Gly-Thr-NH2
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
hydrolysis of pyroglutamyl-Leu-Asn-Phe-Thr-Pro-Asn-Trp-Gly-Thr-NH2 Ascaris suum

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8.8 pH 6.5: about 95% of maximal activity, pH 8.8.: about 40% of maximal activity, hydrolysis of pyroglutamyl-Leu-Asn-Phe-Thr-Pro-Asn-Trp-Gly-Thr-NH2 Ascaris suum